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CDKN1A — HRAS
Pathways - manually collected, often from reviews:
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OpenBEL Selventa BEL large corpus:
CDKN1A
→
HRAS
(increases, CDKN1A Activity)
Yoo et al., Int J Oncol 2006*
Evidence: H-RasG12V expression down-regulated p27Kip1 expression, and that RASSF1A co-transfected with H-RasG12V recovered p27Kip1 expression that had been down-regulated by H-RasG12V expression. Similarly, p21WAF1/CIP1 was induced by H-RasG12V expression and RASSF1A co-transfected with H-RasG12V inhibited p21WAF1/CIP1 induction.
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OpenBEL Selventa BEL large corpus:
CDKN1A
→
HRAS
(increases)
Evidence: We found that Ras activation resulted in elevated expression of p53 (2-fold, P0.05) and p21 (17- fold, P0.01) as well as p16 (5-fold, P0.01; Figure 1B and Data Supplement Figure II), which suggests that Ras-induced growth arrest is different from quiescence, because neither p53 nor p16 accumulates during quiescence.
Text-mined interactions from Literome
Gartel et al., Oncogene 2000
:
Here we show that activated
V12-H-Ras can
induce the
p21 promoter through the same region of the p21 promoter by a p53 independent mechanism in NIH3T3 cells
Bacciocchi et al., Anticancer Res 1992
(Chromosome Aberrations...) :
Enhanced expression of
Ha-ras and c-myc genes
resulted from high
p-21 and p-62 levels
McKay et al., EMBO J 1986
(Cell Transformation, Neoplastic) :
T15 cells have been used to demonstrate that : ( i ) a 20- to 50-fold over-expression of normal
p21ras is required for complete cellular transformation, ( ii )
p21N-ras expression
induces DNA synthesis and the effect can be amplified by epidermal growth factor, ( iii ) moderate increases in normal p21ras expression can influence cell behaviour
Tsunematsu et al., Biochem Mol Biol Int 1997
(Carcinoma, Hepatocellular...) :
However, neither the 10-100 times higher ras
p21 expression required for murine fibroblast transformation by itself nor the mutational
activation of the
H-ras gene was observed in carbon tetrachloride induced hepatic tumors