◀ Back to IL6ST
IL6ST — PTPN11
Pathways - manually collected, often from reviews:
-
NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
→
SHP2 (PTPN11)
(modification, activates)
Lang et al., Nat Immunol 2003, Schaper et al., Biochem J 1998
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL6-mediated signaling events:
SHP2 (PTPN11)
→
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/Hck complex (IL6-IL6R-IL6ST-JAK1-LMO4-HCK)
(modification, collaborate)
Kim et al., Mol Cell Biol 1999, Podar et al., J Biol Chem 2004
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database SHP2 signaling:
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
→
SHP2 (PTPN11)
(modification, activates)
Schaper et al., Biochem J 1998
Evidence: mutant phenotype, physical interaction
-
Reactome Reaction:
PTPN11
→
IL6ST
(indirect_complex)
Stahl et al., Science 1995*, Symes et al., Curr Biol 1997*, Schaper et al., Biochem J 1998
-
Reactome Reaction:
PTPN11
→
IL6ST
(reaction)
Stahl et al., Science 1995*, Symes et al., Curr Biol 1997*, Schaper et al., Biochem J 1998
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
PTPN11
—
IL6ST
(direct interaction, pull down)
Schmitz et al., J Biol Chem 2000
-
IRef Biogrid Interaction:
PTPN11
—
IL6ST
(physical association, affinity chromatography technology)
Lehmann et al., J Biol Chem 2003*
-
IRef Biogrid Interaction:
PTPN11
—
IL6ST
(physical association, affinity chromatography technology)
Kim et al., J Biol Chem 1997*
-
IRef Biogrid Interaction:
PTPN11
—
IL6ST
(physical association, affinity chromatography technology)
Anhuf et al., J Immunol 2000*
-
MIPS CORUM LMO4-gp130 complex:
LMO4-gp130 complex complex (IL6ST-JAK1-LMO4-PTPN11-SOCS3)
Novotny-Diermayr et al., J Biol Chem 2005
-
IRef Corum Interaction:
Complex of SOCS3-JAK1-IL6ST-LMO4-PTPN11
(association, anti tag coimmunoprecipitation)
Novotny-Diermayr et al., J Biol Chem 2005
-
IRef Dip Interaction:
IL6ST
—
PTPN11
(physical association, coimmunoprecipitation)
Kim et al., J Biol Chem 1997*
-
IRef Hprd Interaction:
PTPN11
—
IL6ST
(in vitro)
Anhuf et al., J Immunol 2000*, Lehmann et al., J Biol Chem 2003*, Schiemann et al., J Biol Chem 1997*
-
IRef Hprd Interaction:
PTPN11
—
IL6ST
(in vivo)
Anhuf et al., J Immunol 2000*, Lehmann et al., J Biol Chem 2003*, Schiemann et al., J Biol Chem 1997*
-
IRef Ophid Interaction:
IL6ST
—
PTPN11
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Ozawa et al., Mol Cell Neurosci 2004
:
We demonstrated that STAT3 activation, but not
SHP2 activation, is
responsible for the
CNTF/gp130 signaling that inhibits expression of Rhodopsin and its upstream activator, crx, in the retinal explants derived from P0 mice ( P0 retinal explants ), utilizing STAT3-deficient retina and electroporation of dominant negative form of STAT3 ( STAT3F )
Sands et al., Mol Cell Biol 2006
:
Attenuation of SOCS-3 induction in either ECs or SOCS-3-null murine embryonic fibroblasts abolished the inhibitory effect of cAMP, whereas inhibition of
SHP-2 , another negative
regulator of
gp130 , was without effect