Gene interactions and pathways from curated databases and text-mining

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CDKN1A — MDM2

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Ongkeko et al., Curr Biol 1999 : Moreover, the growth suppression functions of p73 and the induction of endogenous p21 , a major mediator of the p53 dependent growth arrest pathway, were enhanced in the presence of MDM2
Ganguli et al., EMBO J 2000 (Hyperplasia...) : MDM2 inhibits UV induction of p53, the cell cycle inhibitor p21 ( WAF1/CIP1 ) and apoptosis ( ` sunburn cells ' )
Bar et al., Jpn J Cancer Res 2002 (Adenocarcinoma, Clear Cell...) : Induction of MDM2 protein is uncoupled from the cell regulatory machinery and the induction of p21 ( WAF1 ) by p53 is impaired in OvBH-1 cells
Zhang et al., Proc Natl Acad Sci U S A 2003 (Prostatic Neoplasms) : In PC3 cells, MDM2 inhibition resulted in elevated p21 , Bax, and pRb levels and decreased ppRb and E2F1 levels ... In PC3 cells, MDM2 inhibition resulted in elevated p21 , Bax, and pRb levels and decreased ppRb and E2F1 levels
Zhang et al., Ann N Y Acad Sci 2005 : This article summarizes the biochemical and molecular studies of the role of MDM2 in the regulation of p21 and E2F1 expression, stability and function, providing evidence for the utility of RNA silencing technologies, including antisense oligonucleotides and siRNAs
Phillips et al., Cell Death Differ 2007 (Rhabdomyosarcoma) : Ceramide induced G2 arrest in rhabdomyosarcoma ( RMS ) cells requires p21Cip1/Waf1 induction and is prevented by MDM2 overexpression ... Further, adopting the recent discovery that murine double minute 2 (MDM2) controls p21 ( Cip1/Waf1 ) expression by presenting this CDK inhibitor to the proteasome for degradation, RD cells overexpressing MDM2 abrogated ceramide mediated p21 ( Cip1/Waf1 ) induction, G ( 2 ) arrest and the late ensuing apoptosis
Jin et al., Mol Cell Biol 2008 : These results demonstrate that MDMX and MDM2 independently and cooperatively regulate the proteasome mediated degradation of p21 at the G ( 1 ) and early S phases
Mu et al., Prostate 2008 (Prostatic Neoplasms) : AS-MDM2 caused significant reductions in MDM2 and AR expression, and increases in p53 and p21 expression in both cell lines
Zhang et al., J Biol Chem 2008 : Overexpression of p21 suppressed MDM2 , elevated p53 levels, and enhanced CD95, BAX, NOXA, and PUMA expression ; knockdown of BAX/NOXA/PUMA reduced CDK inhibitor stimulated cell killing
Enge et al., Cancer Cell 2009 : MDM2 dependent downregulation of p21 and hnRNP K provides a switch between apoptosis and growth arrest induced by pharmacologically activated p53 ... We uncovered that MDM2 released from p53 by RITA promotes degradation of p21 and the p53 cofactor hnRNP K, required for p21 transcription ... Functional studies revealed MDM2 dependent inhibition of p21 as a key switch regulating cell fate decisions upon p53 reactivation
Jeon et al., J Biol Chem 2009 : ZBTB2 repressed transcription of the ARF, p53, and p21 genes, but activated the HDM2 gene
Xu et al., J Biol Chem 2010 (Neoplasms) : MDM2 promotes proteasomal degradation of p21Waf1 via a conformation change ... The present study was designed to characterize the mechanism ( s ) by which MDM2 induces p21 ( Waf1 ) degradation ... We found that the MDM2-p21 ( Waf1 ) interaction depended on the central domain of MDM2 and that nuclear localization of both proteins was necessary for p21 ( Waf1 ) degradation
Moiseeva et al., Aging Cell 2011 : This senescent phenotype was accompanied by engagement of the p53 tumor suppressor and induction of the p53 target gene p21 and was prevented by small hairpin RNAs against p53, p21, or by the oncoprotein Mdm2
Mungamuri et al., Nature structural & molecular biology 2012 : SUV39H1 downregulation was mediated transcriptionally by p21 and post-translationally by MDM2
Wang et al., Eur J Cancer 2013 (Stomach Neoplasms) : MDM2 contributes to miR-17-5p/20a function and inhibition of p21 in gastric cancer, and may be a novel mechanism underlying the oncogenic roles of miR-17-5p/20a
Guerra et al., Oncogene 1997 : Phosphorylation of MDM2 by CK2 holoenzyme in the presence of the p21 ( WAF1/CIP1 ), known to be a potent inhibitor of cyclin dependent protein kinases, also led to a significant reduction of phosphate incorporation into MDM2 indicating that p21 ( WAF1/CIP1 ) does not exclusively inhibit cell cycle kinases