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CEBPB — IL6
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Cha-Molstad et al., J Immunol 2000
:
P50- but not p65 containing dimers were found in nuclei of Hep 3B cells 18 h after stimulation with IL-1beta, when
C/EBPbeta is greatly activated, in the
presence or absence of
IL-6
Niehof et al., J Biol Chem 2001
:
Here we show that
IL-6 controls
LAP/C/EBPbeta gene transcription and identify an IL-6 responsive element in the LAP/C/EBPbeta promoter, which contains no STAT3 DNA binding motif ... However, luciferase reporter gene assays showed that STAT3 activation through the gp130 signal transducer molecule is involved in mediating
IL-6 dependent
LAP/C/EBPbeta transcription ... Further analysis using STAT1/STAT3 chimeras identified specific domains of the protein that are required for the
IL-6 dependent increase in
LAP/C/EBPbeta gene transcription ... Overexpression of the amino-terminal domain of STAT3 blocked the IL-6 mediated response, suggesting that the STAT3 amino terminus has an important function in
IL-6 mediated transcription of the
LAP/C/EBPbeta gene ... These data lead to a model of how tethering STAT3 to a DNA bound complex contributes to
IL-6 dependent
LAP/C/EBPbeta gene transcription
Georganas et al., J Immunol 2000
(Arthritis, Rheumatoid) :
Inhibition of
C/EBPbeta modestly
reduced constitutive and IL-1beta induced
IL-6 by RA FLS, but not by human dermal fibroblasts, and had no effect on IL-8
Agrawal et al., J Immunol 2001
:
Transactivation of C-reactive protein by
IL-6 requires synergistic interaction of
CCAAT/enhancer binding protein beta ( C/EBP beta ) and Rel p50
Hungness et al., J Cell Physiol 2002
:
Transcription factors
C/EBP-beta and -delta
regulate IL-6 production in IL-1beta stimulated human enterocytes ... The
role of
C/EBP-beta and -delta in enterocyte
IL-6 production is not known ... Finally, overexpression of
C/EBP-beta and -delta in IL-1beta treated Caco-2 cells
resulted in a 10-12-fold increase in
IL-6 production
Göransson et al., Int J Cancer 2005
(Fibrosarcoma...) :
Myxoid liposarcoma FUS-DDIT3 fusion oncogene induces
C/EBP beta mediated
interleukin 6 expression ... Knockdown experiments using siRNA against CEBPB transcripts showed that the effect of FUS-DDIT3 on
IL6 expression is
C/EBP beta dependent
Spooner et al., Mol Immunol 2007
(Leukemia P388) :
To examine the
roles of the
C/EBPbeta transactivation and regulatory domains in LPS induced MCP-1 and
IL-6 expression, we expressed various N-terminal truncations and deletions of C/EBPbeta in P388 murine B lymphoblasts, which lack endogenous C/EBPbeta expression and are normally unresponsive to LPS for expression of IL-6 and MCP-1
Isshiki et al., New Biol 1991
:
The recently cloned
nuclear factor NF-IL6 , a potent trans acting
regulator of
IL-6 gene expression, has a region that is highly homologous to the liver-specific transcriptional factor C/EBP
Cappelletti et al., Cell Death Differ 1996
:
C/EBPbeta is
required for the late phases of acute phase genes induction in the liver and for tumour necrosis factor-alpha, but not
Interleukin-6 , regulation
Xu et al., Stem Cells 2009
:
Furthermore, while STAT1 is critical in IFNgamma signaling, we found that STAT1 knockdown in MSCs did not affect
C/EBPbeta expression or the synergistic
induction of
IL-6 and CXCL1 by IFNgamma and TNFalpha
Gao et al., Mol Immunol 2009
:
Furthermore, ectopic expression of C/EBPzeta inhibited
C/EBPbeta dependent
IL-6 expression from both the endogenous IL-6 gene and an IL-6 promoter-reporter
Qin et al., J Leukoc Biol 2010
:
Bioinformatics analysis identified KSHV miRNA binding sites formiR-K12-3 and miR-K12-7 within the 3'UTR of the basic region/leucine zipper motif transcription factor
C/EBPbeta , a known
regulator of
IL-6 and IL-10 transcriptional activation.Subsequent immunoblot analyses revealed that miR-K12-3 and miR-K12-7 preferentially reduce expression of C/EBPbeta p20 ( LIP ), an isoform of C/EBPbeta known to function as a negative transcription regulator
Atwood et al., Oncogene 2010
:
Upregulation of
interleukin-6 (IL6) by
C/EBPbeta has been shown to be necessary for oncogene induced senescence, but the specific isoform of C/EBPbeta has not been investigated
Screpanti et al., J Exp Med 1996
(Giant Lymph Node Hyperplasia) :
We have previously shown that mice lacking the trans acting factor
C/EBP beta , a transcriptional
regulator of
IL-6 and a mediator of IL-6 intracellular signaling, develop a pathology nearly identical to multicentric Castleman 's disease, together with increasingly high levels of circulating IL-6
Alonzi et al., Immunobiology 1997
(Acute-Phase Reaction...) :
On the other hand, making use of C/EBP beta-deficient mice, we show that the induction of
IL-6 by a variety of stimuli does not
require C/EBP beta activity
Miyazawa et al., J Biol Chem 1998
(Arthritis, Rheumatoid) :
Transcriptional
roles of
CCAAT/enhancer binding protein-beta , nuclear factor-kappaB, and C-promoter binding factor 1 in interleukin (IL)-1beta induced
IL-6 synthesis by human rheumatoid fibroblast-like synoviocytes
Xia et al., Int J Biochem Cell Biol 1997
(Acute-Phase Reaction) :
In addition,
C/EBP beta and C/EBP delta, but not C/EBP alpha, bind specifically to the C/EBP site of SAA2 in
response to
IL-6 stimulation