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MDM1 — MDM2
Text-mined interactions from Literome
Jiang et al., Neurosci Lett 2003
:
After a single morphine injection,
MDM2 gene expression
increased significantly in hippocampus, amygdala and cortex ; however, such up-regulation of
MDM2 gene expression was significantly reduced after repeated morphine administration
Thotala et al., Cell Death Differ 2012
:
These data suggest that the mechanisms of radioprotection by GSK-3ß inhibitors in hippocampal neurons involve regulation of
MDM2 dependent p53 accumulation and interactions between GSK-3ß,
MDM2 and p53
Ray-Coquard et al., Lancet Oncol 2012
(Liposarcoma) :
The primary endpoint was to assess markers of RG7112 dependent
MDM2 inhibition and P53 pathway
activation ( P53, P21,
MDM2 , Ki-67, macrophage inhibitory cytokine-1 [MIC-1 ], and apoptosis )