Gene interactions and pathways from curated databases and text-mining

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MDM1 — MDM2

Text-mined interactions from Literome

Jiang et al., Neurosci Lett 2003 : After a single morphine injection, MDM2 gene expression increased significantly in hippocampus, amygdala and cortex ; however, such up-regulation of MDM2 gene expression was significantly reduced after repeated morphine administration
Thotala et al., Cell Death Differ 2012 : These data suggest that the mechanisms of radioprotection by GSK-3ß inhibitors in hippocampal neurons involve regulation of MDM2 dependent p53 accumulation and interactions between GSK-3ß, MDM2 and p53
Ray-Coquard et al., Lancet Oncol 2012 (Liposarcoma) : The primary endpoint was to assess markers of RG7112 dependent MDM2 inhibition and P53 pathway activation ( P53, P21, MDM2 , Ki-67, macrophage inhibitory cytokine-1 [MIC-1 ], and apoptosis )