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SMAD3 — SOX9
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Furumatsu et al., J Biol Chem 2005
:
Smad3 induces chondrogenesis through the activation of
SOX9 via CREB binding protein/p300 recruitment ... In addition,
Smad3 enhanced the transcriptional activity of
SOX9 and the expression of alpha1 ( II ) collagen gene ( COL2A1 ), and small interference RNA against Smad3 ( si-Smad3 ) inhibited them ... Interestingly, the association between
Sox9 and CBP/p300 was increased by Smad3 overexpression and was
suppressed by
si-Smad3
Hernández-Hernández et al., J Mol Biol 2009
:
Moreover, we provide evidence suggesting that
Smad3 enhances the repressive activity of
Sox9 over alpha-SG gene expression in a transforming growth factor-beta dependent manner
Furumatsu et al., J Biomech 2013
:
In our previous studies, cyclic tensile strain ( CTS ) induces nuclear translocation of transforming growth factor ( TGF ) -ß receptor
regulated Smad2/3 and the master chondrogenic transcription factor
Sry-type HMG box (SOX) 9