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IL11 — TNFSF11

Text-mined interactions from Literome

Smith et al., J Bone Miner Res 2004 : In bone marrow and osteoblast cultures treated with PTH, 1,25 ( OH ) 2D3, or IL-11 , RAP inhibited expression of RANKL and significantly suppressed the ratio of RANKL : osteoprotegerin expression
Giuliani et al., Haematologica 2004 (Multiple Myeloma) : Consistently, RANKL did not have a direct effect on myeloma cell survival, but RANKL treatment induced a significant increase of interleukin (IL)-6 and IL-11 secretion by both BMSC and endothelial cells
Zheng et al., Biochem Pharmacol 2013 (Bone Resorption) : Coumermycin A1 also abrogated RANKL induced expression of interleukin-1ß , tumor necrosis factor-a, and inducible nitric oxide synthase in mouse BMMs. Consistent with the in vitro anti-osteoclastogenic effect, the aminocoumarin suppressed lipopolysaccharide induced osteoclast formation and bone loss in in vivo mouse experiments