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ANGPT2 — CYBA

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Chabrashvili et al., Am J Physiol Regul Integr Comp Physiol 2003 (Body Weight) : Compared to Veh, ANG II significantly ( P < 0.005 ) increased the renal cortical mRNA expression of p22phox ( twofold ), Nox-1 ( 2.6-fold ), and Mn-SOD ( 1.5-fold ) and decreased expression of Nox-4 ( 2.1-fold ) and extracellular (EC)-SOD ( 2.1-fold )
Yamagishi et al., Cell Tissue Res 2005 : Furthermore, PEDF inhibited Ang-II induced up-regulation of mRNA levels of p22phox , Nox4, and gp91phox/Nox2, which are membrane components of NADPH oxidase, and its enzymatic activity in HUVEC
Zhong et al., Br J Pharmacol 2008 (Insulin Resistance) : Gene transfer of ACE2 suppressed the expression of p22phox and MIF induced by angiotensin (Ang) II and Ang IV, accompanied by a decreased level of malondialdehyde in cells
Li et al., Yi Chuan 2008 : The result of the present study suggested that siRNA could induce NAD ( P ) H oxidase subunit p22phox gene silence, Ang II could induce ECV-304 aging cultured in vitro, and the possible pathway of endothelial cell aging is that Ang II upregulates p22phox expression, and then enhances the cell ROS level
Ahn et al., The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2010 : Ang II increased the expression levels of p47(phox), p67(phox), and p22(phox) , but EGCG counteracted this effect on p47(phox)