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MAPK1 — MUC1
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
MAPK1
→
MUC1
(increases, MUC1 Activity)
Evidence: Indeed, mucin1 is also overexpressed in breast cancers and tyrosine phosphorylation of the CT domain of MUC1 mucin leads to activation of amitogen-activated protein kinase pathway through the Ras-MEK-ERK2 pathway (38, 39).
Text-mined interactions from Literome
McNamara et al., Am J Respir Cell Mol Biol 2006
:
The induction of
mucin by flagellin in human lung epithelial cells ( NCIH292 ) is
dependent on asialoGM1 ligation, ATP receptor signaling, Ca2+ mobilization, and
Erk1/2 activation
Ríos et al., Exp Eye Res 2008
(MAP Kinase Signaling System) :
The purpose of the study was to determine if OPC-12759 stimulates secretion from conjunctival goblet cells in culture and if it activates the EGF receptor (EGFR) and p44/p42
mitogen activated protein kinase ( MAPK ) to
cause mucin secretion
Román et al., Eukaryotic cell 2009
(Candidiasis) :
Msb2 signaling
mucin controls activation of Cek1
mitogen activated protein kinase in Candida albicans
Besmer et al., Cancer Res 2011
(Carcinoma, Pancreatic Ductal...) :
Treatment with a MEK1/2 inhibitor, U0126, abrogated the enhanced proliferation of the KCM cells but had minimal effect on KCKO cells, suggesting that
MUC1 is
necessary for
MAPK activity and oncogenic signaling
Kato et al., J Immunol 2012
(Lung Diseases...) :
However, overexpression of
MUC1 in HEK293 cells did not
affect NF-?B or
MAPK activation in response to TNF-a
Hodges et al., Exp Eye Res 2012
:
Inhibitors against the EGF receptor and
ERK 1/2 also
blocked Cch stimulated
mucin secretion