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IL6 — SEA

Text-mined interactions from Literome

Correale et al., J Immunol 2009 (Multiple Sclerosis...) : SEA suppressed the LPS induced DCs production of IL-1beta, IL-6 , IL-12, and TNF-alpha and enhanced TGF-beta as well as IL-10 production
Ferreira et al., Mem Inst Oswaldo Cruz 2012 (Chronic Disease...) : We demonstrate that stimulation with SEA induced prominent lymphocyte proliferation and high levels of tumour necrosis factor (TNF)-a, interleukin (IL)-4 and IL-10 secretion in both OST and non infected individuals ( NI )
Tang et al., PloS one 2012 : The production of IL-10 and IL-6 in RAW 264.7 cells, induced by SEA , was responsible for mediating the down-regulation of MHC class II ... Our findings suggest that in RAW 264.7 cells ( 1 ) IFN-? provides a condition for lower concentrations of SEA to attenuate MHC class II expression ; ( 2 ) SEA attenuated IFN-? induced MHC class II expression and the IL-10 and IL-6 production is mediated at least partly by the interaction of SEA with TLR4 ; and ( 3 ) SEA attenuated IFN-? induced MHC class II expression at the transcriptional level
Hobeika et al., Biochem Biophys Res Commun 1996 : A synthetic peptide of this region, SEA ( 121-149 ), blocks SEA binding to class II MHC molecules and induces interleukin-1 and tumor necrosis factor production in monocytes