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HSD11B2 — MAPK15
Text-mined interactions from Literome
Ignatova et al., Am J Physiol Endocrinol Metab 2009
(Carcinoma, Hepatocellular...) :
To our knowledge, this is the first study showing
involvement of p38
MAPK in the TNF-alpha mediated
11beta-HSD1 regulation, and that TNF-alpha stimulates enzyme activity in vivo
Sharma et al., Endocrinology 2009
:
We showed that inhibition of p38
MAPK with the pharmacological inhibitor SB202190
led to an approximately 50 % reduction in
11beta-HSD2 activity, protein, and mRNA in primary human placental trophoblast cells ... In addition, SB202190 decreased the half-life of 11beta-HSD2 mRNA without altering the HSD11B2 promoter activity, indicating that p38
MAPK regulates placental
11beta-HSD2 expression through modulation of 11beta-HSD2 mRNA stability