Wang et al., Cell Death Differ 2006
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RA/BDNF treatment activates Cdk5 mediated PI3K/Akt and ERK pathways ... Inhibition of Cdk5 inhibits PI3K/Akt and ERK phosphorylation and Bcl-2 expression, and thus sensitizes the differentiated cells to DNA-damage
Lalioti et al., Proc Natl Acad Sci U S A 2009
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Insulin activation of Cdk5 requires PI3K signaling
Fuchigami et al., Genes Cells 2013
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We reported previously that Cdk5-p35 phosphorylates Dab1 at Ser400 and Ser491 and the phosphorylation regulates its binding to CIN85 , which is an SH3 containing multiadaptor protein involved in endocytic downregulation of receptor-tyrosine kinases