Gene interactions and pathways from curated databases and text-mining

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IRS1 — PRKCA

Text-mined interactions from Literome

Formisano et al., Mol Cell Biol 2000 (MAP Kinase Signaling System) : In L6hIR cells, inhibition of insulin receptor substrate 1 (IRS-1) expression caused a 90 % decrease in insulin induced PKCalpha and -beta activation and blocked insulin stimulation of mitogen activated protein kinase ( MAPK ) and DNA synthesis
Motley et al., Hypertension 2002 : PMA treatment or PKC-alpha overexpression also inhibited the tyrosine phosphorylation of IRS-1