Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
MEF2C
→
MAP2K1
(increases, MAP2K1 Activity, MEF2C Activity)
Allen et al., J Biol Chem 2002* Evidence: Here, we investigated the signaling cascade required for Ark inhibition of the GnRH promoter in GT1-7 GnRH neuronal cells. Ark repression was blocked by the MEK/ERK pathway inhibitor, PD98059, and dominant negative MEK1 but was unaffected by dominant negative Ras.