Gene interactions and pathways from curated databases and text-mining

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MAP2K1 — MEF2C

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: MEF2C → MAP2K1 (increases, MAP2K1 Activity, MEF2C Activity) Allen et al., J Biol Chem 2002*
    Evidence: Here, we investigated the signaling cascade required for Ark inhibition of the GnRH promoter in GT1-7 GnRH neuronal cells. Ark repression was blocked by the MEK/ERK pathway inhibitor, PD98059, and dominant negative MEK1 but was unaffected by dominant negative Ras.