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IGF1 — MLST8
Text-mined interactions from Literome
Cybulski et al., Proc Natl Acad Sci U S A 2009
(Fatty Liver) :
mTORC2 , which consists of rictor, mSIN1, mLST8, and mTOR, is
activated by
insulin/IGF1 and phosphorylates Ser-473 in the hydrophobic motif of Akt/PKB
Burgos et al., Domest Anim Endocrinol 2010
:
In addition,
IGF-1 stimulated
mTORC1 kinase activity toward 4E-BP1 in vitro
Dennis et al., J Biol Chem 2013
:
These findings were extended to a cell culture system wherein loss of 4E-BP1 and 4E-BP2 resulted in elevated interaction of p70S6K1 with
IGF1 induced activation of
mTORC1 in conjunction with an enhanced rate of p70S6K1 phosphorylation at Thr-389
Melnik et al., Hautarzt 2013
(Acne Vulgaris...) :
mTORC1 , the central hub of protein- and lipid biosynthesis, cell growth and proliferation, is
activated by insulin,
IGF-1 and branched-chain essential amino acids, especially leucine ...
mTORC1 , the central hub of protein- and lipid biosynthesis, cell growth and proliferation, is
activated by insulin,
IGF-1 and branched-chain essential amino acids, especially leucine