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AKT2 — CALM3
Text-mined interactions from Literome
Chen et al., J Biol Chem 2002
:
Calcium/calmodulin dependent protein kinase kinase ( CaMKK ) and
Akt are two multifunctional kinases involved in many cellular responses
Spicer et al., Endocr Pathol 2003
:
Research over the last few years has revealed that the hypoxia response in PC12 cells involves the interactions of several signal transduction pathways (
Ca2+/calmodulin dependent kinases,
Akt , SAPKs, and MAPKs ) and transcription factors ( HIFs, CREB, and c-fos/junB )
Deb et al., J Biol Chem 2004
:
Calmodulin mediated activation of
Akt regulates survival of c-Myc overexpressing mouse mammary carcinoma cells ... We now demonstrate that EGF induced
Akt activation and survival in transgenic mouse mammary tumor virus-c-Myc mouse mammary carcinoma cells are both
calcium/calmodulin dependent ... EGF induced and
calcium/calmodulin mediated
Akt activation occurs in both tumorigenic and non-tumorigenic mouse and human mammary epithelial cells, independent of their overexpression of c-Myc
Yano et al., J Pharmacol Sci 2005
(Brain Ischemia) :
We here observed that
CaM-KK could directly
activate Akt , thereby preventing apoptosis in cultured cells
Siarey et al., J Neurochem 2006
(Down Syndrome) :
Here we report that
calcium/calmodulin dependent protein kinase II ( CaMKII ), phosphatidylinositol 3-kinase
(PI3K)/Akt , extracellular signal regulated kinase ( ERK ), protein kinase A (PKA) and protein kinase C ( PKC ), all of which have been shown to be involved in synaptic plasticity, are altered in the Ts65Dn hippocampus
Lahair et al., Antioxid Redox Signal 2006
:
In contrast, hydrogen peroxide induced phosphorylation of Akt on serine 473 ( S473 ) was downregulated by both PI3K and CaM-K inhibition, indicating that hydrogen peroxideinduced phosphorylation of
Akt on S473 was largely
dependent on both PI3K and a
CaM-K activity
Xu et al., Hippocampus 2007
(Brain Infarction...) :
Subtoxic N-methyl-D-aspartate delayed neuronal death in ischemic brain injury through TrkB receptor- and
calmodulin mediated
PI-3K/Akt pathway activation ... W-13, an active CaM inhibitor, prevented the combination of
CaM and p85 and subsequent
Akt activation
Coticchia et al., Breast Cancer Res Treat 2009
(Breast Neoplasms) :
Suppression of
calmodulin expression by siRNAs against all three calmodulin genes in c-Myc overexpressing mouse mammary carcinoma cells
results in significant inhibition of EGF induced
Akt activation ... However, forced overexpression of either epidermal growth factor receptor (EGFR) or ErbB2 did partially restore
calmodulin dependent EGF stimulated
Akt activation ... In an attempt to address how
calmodulin is
regulating Akt activity, we looked at localization of fluorescently tagged Akt and calmodulin in MCF-7 and SK-BR-3 cells ... Thus,
calmodulin may be
regulating Akt activity by modulating its sub-cellular location and is a novel target in the poor prognosis, ER-negative subset of breast cancers
Song et al., J Biol Chem 2010
:
We found that Ser-21/9 phosphorylation of GSK-3 was mediated by Ca ( 2+ )
/calmodulin dependent protein kinase II ( CaMKII ) but not by
Akt/PKB , PKA, or p90 ( RSK )
O'Neill et al., Theriogenology 2012
:
These mediators act via 1-o-phosphatidylinositol-3-kinase signaling which has the dual effects of activating
calcium/calmodulin dependent kinase/CREB transcription factor and
AKT ( protein kinase B ) /MDM2 mediated survival pathways
Han et al., Mol Nutr Food Res 2012
:
Moreover, capsaicin increased the activation of the transient receptor potential vanilloid type-1 receptor downstream signaling components
Ca²?/calmodulin dependent protein kinase and
Akt
Cao et al., PLoS Biol 2013
(Angelman Syndrome) :
In Ube3A deficient mice, the BDNF induced recruitment of PSD-95, as well as PLC? and Grb2 associated binder 1 (Gab1) with TrkB receptors was attenuated, resulting in reduced activation of
PLC?-a-calcium/calmodulin dependent protein kinase II ( CaMKII ) and
PI3K-Akt , but leaving the extracellular signal regulated kinase ( Erk ) pathway intact
Farrer et al., J Biol Chem 2013
(Neurofibromatosis 1) :
Akt also co-immunoprecipitated with CaM in a PDGF-BB dependent manner, suggesting that direct interaction between Akt and
CaM is
involved in the sustained phosphorylation of
Akt