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AKT2 — FGFR3
Text-mined interactions from Literome
Kakinuma et al., FEBS Lett 2005
(Anoxia...) :
ACh increased
Akt phosphorylation, and wortmannin or atropine blocked this effect
Philipp et al., Basic Res Cardiol 2006
(Myocardial Infarction) :
In isolated hearts,
ACh caused phosphorylation of both
Akt and ERK
Zecchin et al., Diabetes 2007
(Obesity) :
In addition,
ACh induces JAK2/IRS-1 and IRS-1/phosphatidylinositol (PI) 3-kinase associations, downstream activation of
Akt/protein kinase B, endothelial cell-nitric oxide synthase ( eNOS ), and extracellular signal regulated kinase ( ERK ) -1/2
Huang et al., Mol Carcinog 2009
(Liver Neoplasms, Experimental) :
Analysis of activation of Erk, JNK, and PI3K related AKT signaling pathways indicated that in contrast to FGFR1,
FGFR4 failed to sustain Erk activation and did not
activate AKT
di Martino et al., Oncogene 2009
(Cell Transformation, Neoplastic...) :
In TERT-NHUC, all mutant forms of
FGFR3 induced phosphorylation of FRS2alpha and ERK1/2, but not
AKT or SRC ... In contrast to TERT-NHUC, expression of mutant
FGFR3 in NIH-3T3
resulted in phosphorylation of Src and
Akt
Asomugha et al., J Neurochem 2010
:
ELISA results demonstrated that
ACh significantly
increased phosphorylated
Akt and decreased p38 MAPK
Qiu et al., Zhongguo Zhong Xi Yi Jie He Za Zhi 2010
(Alzheimer Disease...) :
As compared with the model group, the escape latency ( within the 2nd to 5th day ) decreased ( P < 0.01 ), levels of
Ach and 5-HT increased ( P < 0.05 ), and Gab1 protein expression increased ( P < 0.01 ) in the QKL treated group after treatment, in addition, the level of phosphorylated
AKT protein significantly
increased ( P < 0.05 )
Juanpere et al., Hum Pathol 2012
(Carcinoma, Transitional Cell...) :
Single
FGFR3 or PIK3CA mutations and the different mutation combinations FGFR3-PIK3CA/AKT1 and PIK3CA-RAS can
activate the
AKT but not the MAPK pathway
Mavila et al., PloS one 2012
(Liver Neoplasms) :
FGF Receptor ( R ) activation
resulted in the downstream activation of MAPK,
PI3K-AKT , and ß-catenin pathways, as well as cellular proliferation
Nie et al., PloS one 2013
(Carcinoma, Hepatocellular...) :
STAT3 and
AKT phosphorylation was
activated by
Ach in HCC cells