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AKT2 — TIMP1

Text-mined interactions from Literome

Lambert et al., Biochem J 2003 (Leukemia, Erythroblastic, Acute) : Moreover, TIMP-1 enhances specific phosphorylation of both Akt and Bad ( Bcl-2/Bcl-X ( L ) -antagonist, causing cell death ) in a PI 3-kinase dependent manner and, besides, controls the level of the anti-apoptotic protein Bcl-X ( L )
Lee et al., Biochem Biophys Res Commun 2003 (Breast Neoplasms) : TIMP-1 induced phosphorylation of Akt and extracellular signal regulated protein kinases ( ERKs ), but pertussis toxin and specific inhibitors of Src family tyrosine kinases, protein tyrosine kinases, and phosphatidylinositol-3 kinase ( PI3 kinase ) blocked the ability of TIMP-1 to activate Akt and ERKs as well as the anti-apoptotic effect of TIMP-1
Qiu et al., Reproduction 2004 (MAP Kinase Signaling System) : In addition, expression of constitutively active Akt ( Myr-Akt1, Myr-Akt2, Myr-Akt3 ) was not sufficient to induce proMMP-9 and TIMP-1 secretion
Kadri et al., Mol Cell Biol 2005 : We report here that erythropoietin regulates the transcription of the TIMP-1 gene upon binding to its receptor in erythroid cells by triggering the activation of phosphatidylinositol 3-kinase (PI3K)/Akt ... We found that Akt directly phosphorylates the transcription factor GATA-1 at serine 310 and that this site-specific phosphorylation is required for the transcriptional activation of the TIMP-1 promoter
Zhou et al., J Allergy Clin Immunol 2007 (Asthma...) : In contrast, phosphoinositide-3 kinase-Akt inhibition increased phosphorylation of ERK and Smads, leading to increased TIMP-1
Bigelow et al., Breast Cancer Res Treat 2009 (Breast Neoplasms) : However, overexpression of TIMP-1 in MDA-MB-231 cells resulted in inhibition of cell invasion and enhanced phosphorylation of p38 MAPK and AKT in vitro
Jiang et al., Chin Med J (Engl) 2011 : TIMP-1 stimulated Akt phosphorylation
Fu et al., Biomed Pharmacother 2011 (Breast Neoplasms) : TIMP-1 can potently activate phosphatidylinositol 3-kinase (PI3K)/Akt and nuclear factor-kappaB ( NF-?B ) signaling
Ridnour et al., PloS one 2012 (Breast Neoplasms) : Nitric oxide synthase and breast cancer : role of TIMP-1 in NO-mediated Akt activation
Shen et al., Circ Res 2013 (Aneurysm, Dissecting...) : In cultured human aortic vascular smooth muscle cells, AKT2 inhibited the expression of MMP-9 and stimulated the expression of TIMP-1 by preventing the binding of transcription factor forkhead box protein O1 to the MMP-9 and TIMP-1 promoters