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BCL6 — GATA3
Text-mined interactions from Literome
Kusam et al., J Immunol 2003
:
Consistent with the idea that
BCL-6 represses
GATA-3 expression, we found that GATA-3 levels are up-regulated in BCL-6 ( -/- ) STAT6 ( -/- ) CD4 T cells compared with STAT6 ( -/- ) CD4 T cells ... Retrovirus mediated expression of
BCL-6 in both BCL-6 ( -/- ) STAT6 ( -/- ) and wild-type T cells also
leads to a significant decrease in
GATA-3 protein levels
Sawant et al., J Immunol 2012
(Pneumonia) :
Bcl6 potently
repressed Gata3 transcriptional transactivation, providing a mechanism for the increased expression of Th2 genes by Bcl6 ( -/- ) Tregs