Gene interactions and pathways from curated databases and text-mining

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HCCS — PTGS2

Text-mined interactions from Literome

Kern et al., Liver Int 2006 (Carcinoma, Hepatocellular) : In two of three cases, COX-2 inhibition significantly increased tumor cell apoptosis in HCCs , whereas the low basal apoptosis rate in the non-tumorous liver parenchyma did not change
Kern et al., Verh Dtsch Ges Pathol 2007 (Carcinoma, Hepatocellular...) : Selective COX-2 inhibition led to a marked tumor-specific growth inhibition of human HCCs in vitro, in vivo and ex vivo based on reduction of proliferation and induction of apoptosis