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CSRP1 — NOS3

Text-mined interactions from Literome

Sjöholm et al., Lancet 2005 (Arteriosclerosis...) : Subodh Verma and associates ( Circulation 2004 ; 109 : 2058-67 ) recently showed that CRP attenuates the survival, differentiation, and function of endothelial progenitor cells, partly by CRP reducing expression of endothelial nitric-oxide synthase
Mineo et al., Circ Res 2005 : Thus FcgammaRIIB mediates CRP inhibition of eNOS via PP2A, providing a mechanistic link between CRP and endothelial dysfunction
Xu et al., Mol Endocrinol 2007 (Insulin Resistance...) : Recombinant CRP suppressed insulin induced NO production, inhibited the phosphorylation of Akt and endothelial nitric oxide synthase , and stimulated the phosphorylation of IRS-1 at the Ser307 site in a dose dependent manner
Tanigaki et al., Circ Res 2009 : We previously showed that CRP inhibits eNOS activation by insulin by blunting Ser1179 phosphorylation ... Thus, CRP inhibits eNOS stimulation by insulin via FcgammaRIIB and its ITIM, SHIP-1 activation, and resulting blunted activation of Akt
Tanigaki et al., Diabetes 2013 (Insulin Resistance) : CRP does not impair skeletal muscle glucose delivery in Fc?RIIB ( -/- ) mice or in endothelial nitric oxide synthase knock-in mice with phosphomimetic modification of Ser1176, which is normally phosphorylated by insulin signaling to stimulate nitric oxide mediated skeletal muscle blood flow and glucose delivery and is dephosphorylated by CRP/Fc?RIIB