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MMP2 — TGFB2

Text-mined interactions from Literome

Gallery et al., Microvasc Res 1999 (Pre-Eclampsia...) : Neither tumor necrosis factor-alpha nor transforming growth factor-beta , both thought to have significant roles in the control of placentation, affected MMP secretion
Meisser et al., Mol Hum Reprod 1999 : The aim of this study was to determine the effects of tumour necrosis factor alpha (TNF), interleukin-1 alpha (IL-1alpha), macrophage colony stimulating factor ( MCSF ) and transforming growth factor beta ( TGFbeta ) on the secretion of matrix metalloproteinases ( MMP ) , human chorionic gonadotrophin ( HCG ) and fetal fibronectin ( fFN ) by purified first trimester cytotrophoblastic cells (CTB) in vitro
Nuttall et al., Endocrinology 2000 : There was no effect of these growth factors on gelatinase or TIMP-1, -2, and -3, nor was there an effect of transforming growth factor-beta on any MMP or TIMP examined
Jain et al., Br J Surg 2000 (Proteinuria...) : This was associated with increasing expression of tissue inhibitor of metalloproteinases ( TIMP ) 1, an inhibitor of MMP-2 , and of transforming growth factor ( TGF ) beta , a profibrotic cytokine, by 24 weeks following injury
Parkin et al., Eur J Ophthalmol 2000 (Keratoconus) : It is known that platelet derived growth factor ( PDGF ) and transforming growth factor-beta ( TGF-beta ) are involved in the regulation of MMP activity and tissue inhibitor of metalloproteinase ( TIMP ) production in non-ocular tissues
Wick et al., J Neurooncol 2001 (Brain Neoplasms...) : Here, we demonstrate that TGF-beta2 induces MMP-2 expression and suppresses tissue inhibitor of metalloproteinases ( TIMP ) -2 expression and that concentration-dependently promotes the invasion of U87MG and LN-229 glioma cells in a matrigel invasion assay
Wormstone et al., Invest Ophthalmol Vis Sci 2002 (Cataract) : TGF-beta2 also induced sustained release of MMP-2 and -9
McLennan et al., Diabetes 2002 (Diabetic Nephropathies) : Also examined were membrane type 1 MMP (MT1-MMP), tissue inhibitors of MMPs (TIMP)-1 and -2, and transforming growth factor-beta ( TGF-beta ), which together regulate MMP-2 activities in an interacting manner
Shan et al., J Biol Chem 2005 (Adenocarcinoma...) : In contrast, transforming growth factor-beta1 induced accumulation of MMP-2 was unaffected by DRB
Jenniskens et al., Osteoarthritis Cartilage 2006 : TGFbeta2 and IGF1 had no effect on MMP activity
Boyan et al., J Steroid Biochem Mol Biol 2007 : Others have shown that MMP-2 specifically activates TGF-beta2
Neumann et al., Invest Ophthalmol Vis Sci 2008 : TGF-beta2 increased the expression of elastin ( 5X [ rtPCR ] /6X [ WB ] ), ColVIalpha2 ( 3X/5X ), ColVIalpha3 ( 7X/9X ), MMP-2 ( 2X/2X ), TIMP-1/-3 ( 1.5X/2X ), and PAI-1 ( 8X/4X ) compared to untreated controls
Awasthi et al., Invest Ophthalmol Vis Sci 2008 (Cataract) : Medium from HLE B-3 cultures showed MMP-2 and -9 activities, which were induced by TGF-beta(2) treatment and inhibited by MG132 co-treatment
Do et al., Mol Cancer Res 2008 (Neoplasm Metastasis...) : When cancer cells were cultured on plastic, TGF-beta1, TGF-beta2 , and TGF-beta3 induced pro-matrix metalloproteinase ( MMP ) secretion, loss of cell-cell junctions, down-regulation of E-cadherin, up-regulation of N-cadherin, and acquisition of a fibroblastoid phenotype, consistent with an epithelial-to-mesenchymal transition ... When cancer cells were cultured on a three-dimensional collagen matrix, TGF-beta1, TGF-beta2 , and TGF-beta3 stimulated both pro-MMP and active MMP secretion and invasion
Baumann et al., Neuro Oncol 2009 (Brain Neoplasms...) : Here we demonstrate that TGF-beta2 enhances expression, secretion, and activation of matrix metalloproteinase-2 (MMP-2) and induces the cell surface expression of integrin alpha(v)beta ( 3 ) receptors
Dehnavi et al., Cancer Invest 2009 (Urinary Bladder Neoplasms) : The effect of TGF-beta2 on MMP-2 production and activity in highly metastatic human bladder carcinoma cell line 5637 ... We investigated the effect of TGF-beta(2) on MMP-2 regulation in human bladder carcinoma cell line 5637 ... Zymography, ELISA, and real-time polymerase chain reaction revealed that TGF-beta(2) stimulated MMP-2 production, but the transcription of its gene remained unchanged ... These data suggest that TGF-beta(2) increased MMP-2 at the posttranscriptional level and this upregulation was independent of phosphatidylinositol 3-kinase signaling pathway