Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
NOS3
→
ADORA1
(increases, ADORA1 Activity, NOS3 Activity)
Evidence: FIG. 24. Summary of the signaling pathways involved in the muscarinic regulation of pacemaker activity. In the SAN and AVN, ACh and Ado share the same pathways for signal transduction. ACh binds to the muscarinic M2 receptor, which is coupled to a "direct" G protein-dependent pathway activating Kir3.1/Kir3.4 (GIRK1/GIRK4) channel complexes. Beside this direct pathway, two other "indirect" channel regulation pathways lead to downregulation of intracellular cAMP. In the first cascade of events, th...