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CASP10 — CASP6

Pathways - manually collected, often from reviews:

• WikiPathways Apoptosis: CASP10 → CASP6 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CASP10 — CASP6 (direct interaction, enzymatic study) Srinivasula et al., Proc Natl Acad Sci U S A 1996
• IRef Hprd Interaction: CASP6 — CASP10 (in vitro) Srinivasula et al., Proc Natl Acad Sci U S A 1996

Text-mined interactions from Literome

Allsopp et al., Cell Death Differ 2000 : Caspase 6 activity initiates caspase 3 activation in cerebellar granule cell apoptosis
Cowling et al., Cell Death Differ 2002 : Caspase-6 is the direct activator of caspase-8 in the cytochrome c-induced apoptosis pathway : absolute requirement for removal of caspase-6 prodomain