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CDKN1A — NOTCH1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CDKN1A → NOTCH1 (increases) Sriuranpong et al., Cancer Res 2001*
  Evidence: In DMS53 cells, which have intact Rb protein (23) , both active Notch1 and Notch2 caused specific induction of p21waf1/cip1 as early as 24 h postinfection and correlating with the G1 arrest
• OpenBEL Selventa BEL large corpus: CDKN1A → NOTCH1 (increases) Rangarajan et al., EMBO J 2001*
  Evidence: The RBP-Jkappa protein binds directly to the endogenous p21 promoter and p21 expression is induced specifically by activated Notch1 through RBP-Jkappa-dependent transcription.

Text-mined interactions from Literome

Rangarajan et al., EMBO J 2001 : In differentiating primary keratinocytes in vitro endogenous Notch1 is required for induction of p21WAF1/Cip1 expression, and activated Notch1 causes growth suppression by inducing p21WAF1/Cip1 expression ... The RBP-Jkappa protein binds directly to the endogenous p21 promoter and p21 expression is induced specifically by activated Notch1 through RBP-Jkappa dependent transcription
Noseda et al., Mol Cell Biol 2004 : Activated Notch inhibits mitogen induced upregulation of p21Cip1 and delays cyclin D-cdk4 mediated Rb phosphorylation ... Notch dependent repression of p21Cip1 prevents nuclear localization of cyclin D and cdk4
Mammucari et al., Dev Cell 2005 (Alopecia) : Induction of the p21 ( WAF1/Cip1 ) gene by Notch 1 activation in differentiating keratinocytes is associated with direct targeting of the RBP-Jkappa protein to the p21 promoter
Duan et al., Biol Cell 2006 (Tongue Neoplasms) : Activated Notch1 also led to dramatic increase in p21 ( WAF1/CIP1 ) and p53 expression with decreases in Skp2 ( S-phase kinase associated protein 2 ) and Bcl-2 ( B-cell lymphocytic-leukaemia proto-oncogene 2 ) expression, which may participate in the induction of apoptosis and cell cycle arrest
Rooman et al., Am J Pathol 2006 (Metaplasia) : Chemical inhibition of Notch signaling resulted in increased proliferation and induction of the cell-cycle regulator p21Cip1
Henning et al., Cell Death Differ 2008 : Induction of the p21 ( cip/waf ) gene by activated Notch was mediated by increased binding of p53 to p53 binding sites in the p21 ( cip/waf ) promoter and was independent of the canonical RBP-J binding site
Heo et al., Growth Factors 2008 : Moreover, TGF-alpha increased cyclin D/CDK 4 and cyclin E/CDK 2 levels, while decreasing p21cip1/waf1 and p27kip1, which were blocked by the inhibition of Akt, mTOR and Notch
Garg et al., Gastroenterology 2011 (Colitis...) : Inhibition of Notch1 signaling significantly reduced protein levels of active Notch1, p53, p21WAF1/Cip1 , Bax-1, active caspase-3, as well as apoptosis, compared with controls
Cui et al., Cancer Res 2013 (Neoplasms) : The ability of Notch3 to induce senescence and p21 expression was dependent on the canonical Notch singling