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CDKN1A — RASA1

Text-mined interactions from Literome

Müller et al., Carcinogenesis 1992 (Liver Neoplasms, Experimental) : The GTPase activating proteins (GAP) stimulate the intrinsic GTPase activity of ras-p21 thus converting the protein into its inactive form
Martin et al., Science 1992 : A model is presented that suggests that ras p21 induces a conformational change in GAP , which allows the SH2-SH3 regions of GAP to function
Serth et al., Biochemistry 1992 : Binding of the H-ras p21 GTPase activating protein by the activated epidermal growth factor receptor leads to inhibition of the p21 GTPase activity in vitro
Kawata et al., Oncogene 1991 : The GTPase activities of smg p21A and -B were equally stimulated by smg p21 GTPase activating protein 1 and -2
Hata et al., J Biol Chem 1990 : Inhibition of the ras p21 GTPase activating protein stimulated GTPase activity of c-Ha-ras p21 by smg p21 having the same putative effector domain as ras p21s ... In the present studies, we examined the effects of ras p21 GAP on the GTPase activity of smg p21 purified from human platelets, of smg p21 on the ras p21 GAP stimulated GTPase activity of c-Ha-ras p21 purified from Escherichia coli, and of c-Ha-ras p21 on the smg p21 GAP1- or -2-stimulated GTPase activity of smg p21 ... ras p21 GAP stimulated the GTPase activity of c-Ha-ras p21 but not that of smg p21 ... The GTP bound form of smg p21, however, inhibited the ras p21 GAP stimulated GTPase activity of c-Ha-ras p21 in a dose dependent manner ... The GDP bound form also inhibited the ras p21 GAP stimulated GTPase activity of c-Ha-ras p21, but the efficiency was 40-50 % that of the GTP bound form ... smg p21 GAP1 and -2 stimulated the GTPase activity of smg p21 but not that of c-Ha-ras p21 ... c-Ha-ras p21 did not inhibit the smg p21 GAP1- or -2-stimulated GTPase activity of smg p21
Frech et al., Science 1990 : Rap1A-p21 was not activated by GAP but bound tightly to GAP and was an effective competitive inhibitor of GAP mediated Ras-GTPase activity
Kikuchi et al., J Biol Chem 1989 : smg p21 GAP1 and -2 stimulate the GTPase activity of only smg p21 but not that of c-Ha-ras p21 or the rho and smg-25A GTP binding proteins
Rey et al., Mol Cell Biol 1989 : The apparent inhibitory effect of Y13-259 on stimulation of p21 by GAP was due to a greatly reduced rate of exchange of nucleotides in the binding pocket of the protein
Adari et al., Science 1988 : These results indicate that GAP interaction may be essential for ras p21 biological activity and that it may be a ras effector protein
Sasaki et al., J Biol Chem 1993 : Moreover, rho GDI inhibited both the basal and rho GAP stimulated GTPase activity of rhoA p21 and rac1 p21 in a dose dependent manner