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ANGPT2 — SELP

Text-mined interactions from Literome

Estellés et al., Br J Pharmacol 2003 : 4. Both alkaloids inhibited Ang-II induced endothelial P-selectin upregulation and the generation of reactive oxygen species ( ROS ) in endothelial cells stimulated with Ang-II, in fMLP stimulated human neutrophils ( PMNs ) and in the hypoxanthine-xanthine oxidase system
Maliba et al., J Leukoc Biol 2008 (Calcium Signaling...) : In addition, we demonstrate for the first time that angiopoietin mediated endothelial P-selectin translocation is calcium dependent and regulated through phospholipase C-gamma activation
Tayeh et al., Proc Assoc Am Physicians 1998 : The effects of Ang II on P-selectin expression were not affected by the presence of the NO synthase inhibitor nitro-L-arginine ( L-NA, 5 x 10 ( -4 ) M ) but were abolished by pretreatment with superoxide dismutase ( SOD ) ... Thus, Ang II acting on AT1 receptors stimulates superoxide generation, which, in turn, induces expression of P-selectin on the endothelial cell surface