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PDE3B — PIK3CG

Pathways - manually collected, often from reviews:

• NCI Pathway Database Class IB PI3K non-lipid kinase events: PDE3B (PDE3B) → PI3K Class IB family (PIK3CG/PIK3R6) (modification, collaborate)
  
• NCI Pathway Database Class IB PI3K non-lipid kinase events: PI3K Class IB family (PIK3CG/PIK3R6) → PI3K Class IB/PDE3B complex (PDE3B) (modification, collaborate)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Intact Interaction: Complex of RAPGEF3-PDE3B-PIK3CG (association, anti bait coimmunoprecipitation) Wilson et al., J Biol Chem 2011*
• IRef Intact Interaction: Complex of PDE3B-PIK3R6-PIK3CG-RAPGEF3 (association, anti bait coimmunoprecipitation) Wilson et al., J Biol Chem 2011*
• IRef Intact Interaction: PIK3CG — PDE3B (physical association, anti bait coimmunoprecipitation) Wilson et al., J Biol Chem 2011*

Text-mined interactions from Literome

Patrucco et al., Cell 2004 (Hypertension) : Thus, cardiac PI3Kgamma participates in two distinct signaling pathways : a kinase dependent activity that controls PKB/Akt as well as MAPK phosphorylation and contributes to TAC induced cardiac remodeling, and a kinase independent activity that relies on protein interactions to regulate PDE3B activity and negatively modulates cardiac contractility
Voigt et al., J Biol Chem 2006 : However, coexpression of PDE3B and PI3Kgamma subunits was not sufficient to reconstitute the regulatory effect of PI3Kgamma on PDE3B activity observed in heart, implying further molecules to be present in the complex regulating PDE3B in heart
Perino et al., Biochem Soc Trans 2006 : In this complex, PI3Kgamma could regulate PDE3B activity through protein kinase A, a PDE activator