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PI3 — PRKAB1
Text-mined interactions from Literome
Zong et al., PloS one 2012
(MAP Kinase Signaling System) :
Meanwhile,
PI3-K is
essential for resveratrol mediated phosphorylation of
AMPK and expression of SIRT1
Suzuki et al., Mol Cell 2013
:
Surprisingly,
PI3K-Akt signaling, which is a major anabolic signaling and normally inhibits GSK3 activity,
promotes GSK3 phosphorylation and inhibition of
AMPK , thus revealing how AMPK senses anabolic environments in addition to cellular energy levels