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CDK2 — TFDP1

Pathways - manually collected, often from reviews:

• BioCarta cell cycle: g1/s check point: RB/HDAC/ABL/E2F-1/DP-1 complex (E2F1-RB1-TFDP1-ABL1-HDAC1) → Cyclin E/CDK2 complex (CCNE1-CDK2) (modification, collaborate)
  
• BioCarta cell cycle: g1/s check point: Cyclin E/CDK2 complex (CCNE1-CDK2) → E2F-1/DP-1 complex (TFDP1-E2F1) (modification, activates)
  
• NCI Pathway Database Regulation of retinoblastoma protein: CDK2/Cyclin E1 complex (CDK2-CCNE1) → RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1) (modification, activates)
  Harbour et al., Cell 1999, Chan et al., Nat Cell Biol 2001, Rubin et al., Cell 2005
  Evidence: mutant phenotype, assay, reporter gene, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: p21CIP1/CDK2 complex (CDKN1A-CDK2) → RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1) (modification, inhibits)
  Harbour et al., Cell 1999, Chan et al., Nat Cell Biol 2001, Rubin et al., Cell 2005
  Evidence: mutant phenotype, assay, reporter gene, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: CDK2/Cyclin A complex (CDK2-CCNA2) → RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1) (modification, activates)
  Rubin et al., Cell 2005, Knudsen et al., J Biol Chem 1996
  Evidence: mutant phenotype, assay, physical interaction
• Reactome Reaction: CDK2 → TFDP1 (reaction) Woo et al., Mol Cell Biol 1997*
• Reactome Reaction: CDK2 → TFDP1 (indirect_complex) Woo et al., Mol Cell Biol 1997*

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: TFDP1 — CDK2 (direct interaction, enzymatic study) Dynlacht et al., Mol Cell Biol 1997
• IRef Biogrid Interaction: TFDP1 — CDK2 (physical association, affinity chromatography technology) Dynlacht et al., Mol Cell Biol 1997
• Gene Ontology Complexes transcription factor complex: transcription factor complex complex (ATF7IP-GSC-GCM1-MAFB-NKX2-1-NKX2-5-RARG-KLF4-FOXF1-FOXF2-FOXE3-LDB1-ZFHX3-GATA6-SNAI3-FOXH1-KAT5-AHR-EYA3-NFATC2-CRX-MED27-HES6-SKI-XRCC6-ARNTL-SUB1-JUN-SOX17-SCX-DMBX1-TCF4-TCF7-PDLIM1-TFEB-LBX1-TRRAP-NAA16-EPAS1-MGA-PTF1A-HOXD12-MEF2B-TFDP3-TFDP1-HDAC2-YY1-SMAD9-CLOCK-ONECUT3-SMAD5-SMAD6-SMAD7-SMAD1-SMAD2-PRKDC-RCOR2-NHLH2-REL-TBX5-ARNTL2-BSX-HOXA10-HOXB13-MED23-PUS1-TAL1-RBL1-RBL2-MINA-HMGA1-BARX2-LEF1-EP300-PMF1-ARID5A-WWTR1-LMO2-LMO4-TP73-ABT1-CDK2-DKFZp686M216-CREG1-CTNNB1-SOX9-HAND2-SOX2-TEAD2-MYOG-TEAD4-CEBPA-GFI1B-MYOD1-ALX1-NPAS4-TFAP2D-FIGLA-ALX4-ETS1-PROP1-ASCL3-HCLS1-MSX1-MSX2-SRA1-AJUBA-MTA2-SIN3A-POU3F2-POU3F1-BEX1-MLXIPL-NR2E3-PBX2-ANKRD1-E2F6-E2F5-E2F4-E2F3-E2F2-E2F1-E2F8-CREBBP-ATF5-ATF4-POU2F3) Kaspar et al., J Biol Chem 1999, Wang et al., J Biol Chem 1999, Nagpal et al., J Biol Chem 1999, Blixt et al., Genes Dev 2000, Carlberg et al., Mol Cell Biol Res Commun 2000, Bae et al., Development 2000, Cairo et al., Hum Mol Genet 2001, Tutter et al., Genes Dev 2001, Willis et al., J Biol Chem 2002, Bayne et al., Mol Hum Reprod 2004, Schubert et al., J Biol Chem 2004, Han et al., J Mol Biol 2005, Rodriguez et al., EMBO J 2005, Han et al., Nucleic Acids Res 2005, Zhang et al., Mol Cell Biol 2007, Wong et al., Cell 2009, Stevens et al., Immunology 2009, Stefanovic et al., J Cell Biol 2009, Skokowa et al., Nat Med 2012, Ge et al., Cell 1994, Durocher et al., EMBO J 1997, Hogenesch et al., Proc Natl Acad Sci U S A 1998, Hellqvist et al., J Biol Chem 1998, Ryu et al., Nature 1999
• IRef Hprd Interaction: Complex of 26 proteins (in vivo) Timchenko et al., Mol Cell Biol 1999
• IRef Intact Interaction: Complex of 14 proteins (association, anti tag coimmunoprecipitation) Litovchick et al., Mol Cell 2007
• IRef Intact Interaction: Complex of 14 proteins (association, anti bait coimmunoprecipitation) Litovchick et al., Mol Cell 2007
• MIPS Negatome - no physical interaction between proteins Interaction: TFDP1 — CDK2 (Absence of interaction, coimmunoprecipitation) Xu et al., Mol Cell Biol 1994*

Text-mined interactions from Literome

Xu et al., Mol Cell Biol 1994 : Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA binding activity of E2F-1/DP-1 by phosphorylation
Shan et al., Cell Growth Differ 1996 : Induction of E2F-1/DP-1 resulted in increased expression and activity of cyclins A and E, as well as CDK2 , prior to S-phase entry