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LTB — TNF
Text-mined interactions from Literome
Zinetti et al., Cytokine 1998
(Sepsis) :
Neither the pro-inflammatory cytokines interleukin 2 (IL-2),
TNF-alpha nor LPS alone or in combination with interferon gamma (IFN-gamma)
had any effect on
LT-beta mRNA expression
Amsellem et al., Pulm Pharmacol Ther 1998
:
Moreover, the
TNF-alpha induced stimulation of
LTB4 release that we demonstrated in PMN-HAEC interaction was also inhibited by loratadine
He et al., J Rheumatol 2002
(Osteoarthritis) :
The effect of antiinflammatory cytokines rhIL-4, IL-10, and IL-13 on basal and
LTB4 dependent stimulation of
IL-1beta/TNF-alpha synthesis was studied under titration conditions ...
LTB4 stimulated IL-1beta and
TNF-alpha synthesis with an EC50 of 190 +/- 35 and 45 +/- 9 nmol/l, respectively ... The antiinflammatory cytokine IL-4 blocked
LTB4 dependent stimulation of IL-1beta and
TNF-alpha synthesis
Talvani et al., Infect Immun 2002
(Chagas Disease...) :
LTB ( 4 ) also
induced significant
tumor necrosis factor alpha (TNF-alpha) production, and blockade of TNF-alpha suppressed LTB ( 4 ) -induced NO release and parasite killing
Young et al., Br J Pharmacol 2002
(Inflammation) :
7. The data indicate that firm adhesion and transmigration in mouse cremasteric venules stimulated by IL-1beta, but not
TNFalpha , is protein synthesis dependent and
mediated by endogenous generation of PAF and
LTB ( 4 )
Chen et al., Beijing Da Xue Xue Bao 2006
(Arthritis, Rheumatoid) :
To investigate quantification of expression of
LTB4 inducing IL-1beta and
TNF-alpha at mRNA level in synovial membrane cells of rheumatoid arthritis ... Bestatin ( 100 mg/L ) could also remarkably diminish
LTB4 induced mRNA expressions of
TNF-alpha ( 86 % ) and IL-1beta ( 79 % ) ...
LTB4 of synovial membrance cells in rheumatoid arthritis could
induce expressions of
TNF-alpha and IL-1beta at mRNA level, and their expression at mRNA level had been quantified successfully
Bauldry et al., J Immunol 1991
:
We have further examined the
effects of
TNF-alpha on arachidonic acid ( AA ) release,
LTB4 production, and platelet activating factor (PAF) formation in PMN by prelabeling cells with either [ 3H ] AA or [ 3H ] lyso-PAF, priming with human rTNF-alpha, and then stimulating with the chemotactic peptide, FMLP
Zou et al., Mediators Inflamm 1994
:
However, neither
TNFalpha nor IL-1beta
induced a significant
LTB ( 4 ) production in SMC alone or AM alone after 24 h of incubation
Domingos et al., Toxicon 2009
:
In contrast to the results obtained with the B subunits, incubation of cells with the A subunit of CT (CTA) inhibit
TNF-alpha release
induced by native CT, native LT, recombinant
LTB and LPS
Xu et al., Rheumatol Int 2010
(Arthritis, Rheumatoid) :
Exogenous
LTB4 remarkably
increased the expression of
TNFalpha and IL1beta at both the mRNA level and the protein level
Peng et al., Pharm Biol 2011
(Inflammation) :
PRP extracts were found to
inhibit the production of
TNF-a , IL-1ß, and PGE ( 2 ), reduce the expressions of COX-2 at the mRNA and protein levels induced by LPS, and reduced the production of
LTB4 induced by A23187
Piotrowska-Tomala et al., Domest Anim Endocrinol 2012
(Mastitis, Bovine) :
Tumor necrosis factor , NONOate, and TNF + IL-1a + NONOate
increased LTB ( 4 ) production ( P < 0.01 ), whereas LTC ( 4 ) was increased by LPS, TNF, and IL-1a ( P < 0.01 )
Dubois et al., Am Rev Respir Dis 1989
(Asbestosis...) :
We next examined the
role of
LTB4 in mineral-dust induced
TNF production
Luedke et al., Agents Actions 1989
:
Effect of
tumor necrosis factor on granule release and
LTB4 production in adherent human polymorphonuclear leukocytes
Goldman et al., Surgery 1993
:
Pretreatment of rats by lavage into airways with actinomycin D, 12 ng in 0.1 ml, minimized
LTB4 induced
TNF synthesis after 1 1/2 and 3 hours ( 38 and 51 pg/ml ), as well as the delayed diapedesis after 4 hours ( 12 PMN/ml ) ( all p < 0.05 )
Steadman et al., Int J Biochem Cell Biol 1996
:
DiC8 and
TNF alpha in combination, however, synergistically
increased LTB4 release ... In contrast, at concentrations above 10-8 M DiC8, whether in the
presence or absence of
TNF alpha ,
LTB4 release was inhibited and this was ameliorated by protein kinase C inhibitors
Ferreri et al., Cytokine 1997
:
These results demonstrate that PGE2 does not affect
LT-beta , IL-4, or IL-3 in Th2 cells, but
inhibits TNF mRNA accumulation and production in this T cell subset
Denizot et al., Biochim Biophys Acta 1998
:
Bone marrow stromal cells release PGE2 and
LTB4 in
response to phorbol myristic acetate ( PMA ) ( 1 microM ) and
tumor necrosis factor alpha (TNF-alpha) ( 10 ng/ml )