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NUP43 — TNF
Text-mined interactions from Literome
Hernández et al., J Neurochem 1999
(Astrocytoma...) :
In contrast,
TNF-alpha did not
activate the extracellular signal regulated kinase ( MAP kinase )
p42 , nor did it elicit a mitogenic response
Engelman et al., Mol Endocrinol 2000
(Insulin Resistance) :
These activation kinetics suggest a mechanism of p42/44 action more complicated than a direct phosphorylation of IRS-1 triggered by the early spike of
TNFalpha induced
p42/44 activity
Schröder et al., J Biol Chem 2001
:
Phosphorylation of
p42/44 correlated with an increase of activity, and
tumor necrosis factor-alpha levels were significantly
reduced by addition of inhibitors of p42/44 and p38, PD 98059 and SB 203580, respectively
Mollapour et al., Blood 2001
(MAP Kinase Signaling System) :
PD98059 inhibited the
activation of
p42 ( ERK2 ) by GM-CSF,
TNF-alpha , and FMLP, but it did not inhibit FMLP stimulated superoxide production in either unprimed or primed neutrophils
Saijonmaa et al., J Vasc Res 2001
:
TNF-alpha and IL-1beta
activated p44/42 and p38 mitogen activated protein kinases ( MAPKs ) in HUVECs ; this was inhibited by the specific inhibitors of these kinases, PD98059 and SB202190, respectively
Hideshima et al., Oncogene 2001
(MAP Kinase Signaling System...) :
In this study we demonstrate that
tumor necrosis factor alpha (TNFalpha) triggers only modest proliferation, as well as
p44/p42 mitogen activated protein kinase ( MAPK ) and NF-kappaB activation, in MM.1S multiple myeloma ( MM ) cells
Hsu et al., Cell Signal 2001
(MAP Kinase Signaling System) :
Furthermore, overexpression of dominant negative mutants, H-Ras-15A and Raf-N4, significantly suppressed
p42/p44 mitogen activated protein kinase ( MAPK ) activation
induced by
TNF-alpha and PDGF-BB and attenuated the effect of TNF-alpha on BK-induced IP response, indicating that Ras and Raf may be required for activation of these kinases
Liu et al., Acta Pharmacol Sin 2001
:
TNF-alpha simultaneously
activates p38 CCDPK and
p44/42 CCDPK, and these two CCDPK signaling pathways appeared to play opposing roles in TNF-alpha induced apoptosis in BAEC
Kerby et al., Am J Physiol Lung Cell Mol Physiol 2002
(Cystic Fibrosis...) :
Strikingly, the
activation of
p42 ( mapk/erk2 ) and Akt by
TNF-alpha was also inhibited in the presence of NaCl
Chen et al., Kidney Int 2003
:
The present data indicate that
TNF-alpha activation of PKCzeta/iota,
p42/44 MAPK, c-Jun/AP-1, and p65/NF-kappaB are involved in TNF-alpha stimulated MC fractalkine expression, with the soluble fractalkine mediating in part the TNF-alpha induced monocyte transmigration in vitro
Niwa et al., Eur J Pharmacol 2003
:
TNF-alpha induced the phosphorylation of
p44/p42 mitogen activated protein ( MAP ) kinase and p38 MAP kinase
Suo et al., J Biol Chem 2003
(MAP Kinase Signaling System) :
Mechanistic studies indicated that, in comparison with PAR1 signaling, prolonged increase of [ Ca2+ ] i and phosphorylation of
p44/42 mitogen activated protein kinases, as well as NFkappaB activation may be
responsible for PAR4AP induced
TNF-alpha production in microglia
Lin et al., Cell Signal 2004
:
This hypothesis was further supported by that
TNF-alpha induced a transient activation of
p42/p44 and p38 MAPKs in a time-and concentration dependent manner
Takada et al., J Biol Chem 2004
:
Deletion of GSK-3beta also abolished
TNF induced c-Jun N-terminal kinase and
p44/p42 mitogen activated kinase activation
Hernandez et al., Diabetologia 2004
(Insulin Resistance) :
Rosiglitazone ameliorates insulin resistance in brown adipocytes of Wistar rats by impairing
TNF-alpha induction of p38 and
p42/p44 mitogen activated protein kinases ... Rosiglitazone treatment impaired
TNF-alpha activation of p38 and
p42/p44MAPK , restoring insulin signalling and leading to normalisation of glucose uptake
Kralisch et al., Mol Cell Endocrinol 2005
:
Moreover,
p44/42 mitogen activated protein kinase appears to partly
mediate the negative effect of insulin but not
TNFalpha on ATGL
Yasui et al., Cancer Res 2005
(Multiple Myeloma) :
Finally, it down-regulates interleukin-6 induced phosphorylation of Akt, signal transducers and activators of transcription 3, and
p42/44 mitogen activated protein kinase ; insulin-like growth factor-I triggered Akt phosphorylation ; and
tumor necrosis factor alpha
induced IkappaBalpha and nuclear factor-kappaB p65 phosphorylation
Sandra et al., Oral Oncol 2006
(Ameloblastoma...) :
These results suggested that TNFalpha induced both cell survival and apoptosis pathways in ameloblastoma and potential of TNFalpha in inducing apoptosis can be improved by inhibiting
TNFalpha induced Akt and
p44/42 mitogen activated protein kinase ( MAPK ) cell survival pathways
Cheng et al., Environ Health Perspect 2006
:
We examined the cells responsible for the excess production of Pb-increased LPS induced TNF-alpha and liver injury, and the
roles of protein kinase C ( PKC ) and
p42/44 mitogen activated protein kinase ( MAPK ) in the induction of
TNF-alpha
Ahn et al., J Biol Chem 2006
:
Further, the deletion of NQO1 abolished
TNF induced c-Jun N-terminal kinase, Akt, p38, and
p44/p42 mitogen activated protein kinase activation
Shi et al., Osteoarthritis Cartilage 2007
(Osteoarthritis) :
Upon examination of the signaling components, we found that
TNFalpha was a potent
activator of p38,
p44/42 , p54/46 MAPK, and IkappaBalpha ( IkappaBalpha )
Kesherwani et al., Cytokine 2007
:
Quantitative
role of
p42/44 and p38 in the production and regulation of cytokines
TNF-alpha , IL-1beta and IL-12 by murine peritoneal macrophages in vitro by concanavalin A ... In the present study the quantitative
role of
p42/44 and p38 in the production of
TNF-alpha , IL-1beta and IL-12 by murine peritoneal macrophages, in vitro, on treatment with Concanavalin A ( ConA ) has been investigated ... The expression of TNF-alpha, IL-1beta and IL-12 was down regulated in the presence of PD98059 and SB202190 in a dose dependent manner, suggesting the involvement of
p42/44 and p38 in ConA
induced production of
TNF-alpha , IL-1beta and IL-12 by macrophages
Sodhi et al., Glycoconj J 2007
:
Pharmacological inhibitor of tyrosine kinase, PI3 kinase, protein kinase C,
p42/44 , p38, JNK and intracellular calcium immobilizing agent down
regulated the WGA induced expression of cytokines
TNF-alpha , IL-1beta, IL-12 and IFN-gamma
Ahn et al., Cancer Res 2007
(Skin Neoplasms) :
Deletion of NQO2 also abolished
TNF induced c-Jun NH2-terminal kinase, Akt, p38, and
p44/p42 mitogen activated protein kinase activation
Rivas et al., Exp Cell Res 2008
(Carcinoma, Ductal, Breast...) :
We demonstrate that
TNFalpha induced proliferation of C4HD murine mammary tumor cells and of T47D cells through the activation of
p42/p44 MAPK, JNK, PI3-K/Akt pathways and nuclear factor-kappa B (NF-kappa B) transcriptional activation
Jiang et al., Infect Immun 2008
:
It was shown that these three proteins could ( i ) induce expression of
tumor necrosis factor alpha (TNF-alpha) and tissue factor and ( ii ) induce phosphorylation of
p44/42 mitogen
activated protein kinases ( MAPK ) and activation of early growth response factor 1 (Egr-1)
Zeng et al., J Hepatol 2009
(Reperfusion Injury) :
In contrast, RAGE stimulated Egr-1 independent pathways
regulate TNF-alpha production and apoptosis in response to I/R. Consistent with these findings,
phospho-p44/42 and phospho-JNK MAPK and c-Jun were strikingly suppressed in RAGE ( -/- ) versus WT mice, but not in Egr-1 ( -/- ) mice
Eda et al., Rheumatol Int 2011
(MAP Kinase Signaling System) :
IL-1ß and
TNF-a activated the intracellular mitogen activated protein kinases ( MAPKs )
: p44/42 MAPK, p38, and c-Jun N-terminal kinase (JNK) as well as nuclear factor-?B ( NF-?B ) in osteoblasts
Lee et al., J Cell Physiol 2011
:
Here, we report that
TNF-a induced cPLA(2) protein and mRNA expression, PGE ( 2 ) production, and phosphorylation of
p42/p44 MAPK, p38 MAPK, and JNK1/2, which were attenuated by pretreatment with a ROS scavenger [ N-acetyl-L-cysteine, ( NAC ) ] and the inhibitors of NADPH oxidase [ apocynin (APO) and diphenyleneiodonium chloride ( DPI ) ], MEK1/2 ( U0126 ), p38 MAPK ( SB202190 ), and JNK1/2 ( SP600125 ) or transfection with siRNA of Nox2, p47(phox), MEK1, p42, p38, or JNK2
Yang et al., Biochem Pharmacol 2013
:
We further demonstrated that
TNF-a markedly
stimulated p38 MAPK,
p42/p44 MAPK, and JNK1/2 phosphorylation via a c-Src/EGFR, PDGFR/PI3K/Akt pathway
Rafiee et al., J Immunol 1995
:
TNF induces a time-and dose dependent increase in tyrosine phosphorylation of
p42 and MAPK activity
Waterman et al., Biochem Biophys Res Commun 1995
:
Since we recently found that
TNF-alpha stimulation of neutrophils does not
increase the tyrosine phosphorylation or activation of the
p42erk2 and p44erk1 mitogen activated protein kinases ( MAPKs ), the present studies demonstrate the involvement of a MAPK independent pathway in the phosphorylation and activation of cPLA2
Schwenger et al., J Biol Chem 1996
:
Inhibition of
tumor necrosis factor induced
p42/p44 mitogen activated protein kinase activation by sodium salicylate ...
Tumor necrosis factor (TNF) activates both
p42 and p44 mitogen activated protein kinases ( MAPK ) in human FS-4 fibroblasts, cells for which TNF is mitogenic
Schwenger et al., Proc Natl Acad Sci U S A 1997
:
In a previous study, we demonstrated that sodium salicylate ( NaSal ) selectively inhibits
tumor necrosis factor (TNF) induced
activation of the
p42 and p44 mitogen activated protein kinases ( MAPKs ) ( known as extracellular signal regulated kinases )
Ferro et al., Am J Physiol 1997
:
The .NO synthase inhibitor aminoguanidine ( 100 microM ) prevented the
TNF-alpha induced increase in NO2-, nitrotyrosine immunofluorescence, oxidized
p42 , and permeability
Flury et al., Eur J Biochem 1997
(Breast Neoplasms) :
A comparable
TNF-alpha mediated
inhibition of
p42/44 mitogen activated protein (MAP) kinase activity was observed in 10 nM EGF stimulated cells
Boone et al., FEBS Lett 1998
(Fibrosarcoma) :
Activation of
p42/p44 mitogen activated protein kinases ( MAPK ) and p38 MAPK by
tumor necrosis factor (TNF) is mediated through the death domain of the 55-kDa TNF receptor