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TNF — YME1L1

Text-mined interactions from Literome

Crane-Godreau et al., Infect Immun 2005 : Freeze-thaw and cell lysis experiments, along with actinomycin D studies, suggested that CCL20 and TNF-alpha are synthesized in response to PAMP stimulation
Crane-Godreau et al., Infect Immun 2005 : To determine whether estradiol ( E2 ) modulates PAMP induced CCL20/MIP3alpha and TNF-alpha secretion, primary cultures of rat UEC were incubated with E2 for 24 h and then treated with LPS or Pam3Cys or not treated for an additional 12 h. E2 inhibited the constitutive secretion of TNF-alpha and CCL20/MIP3alpha into culture media ... In contrast, and at the same time, E2 lowered the TNF-alpha response to both PAMP ... Since CCL20/MIP3alpha has antimicrobial activity and is chemotactic for immune cells, these studies suggest that regulation of CCL20/MIP3alpha and TNF-alpha by E2 and PAMP may have profound effects on innate and adaptive immune responses to microbial challenge in the female reproductive tract