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CTNNB1 — TGFB1
Text-mined interactions from Literome
Janji et al., Int J Cancer 1999
(Melanoma) :
Our data further illustrate the
TGF-beta1 dependent up-regulation of integrin linked kinase and the nuclear translocation of
beta-catenin , 2 intracellular proteins involved in integrin and cadherin signaling
Xu et al., Cell Res 2003
(Carcinoma, Hepatocellular...) :
Furthermore,
TGF-beta1 induced the down-regulation of E-cadherin and the nuclear translocation of
beta-catenin
Cheon et al., Exp Cell Res 2004
(Cicatrix) :
EGF and
TGF-beta1 significantly
increased beta-catenin protein levels and transcriptional activity, whereas beta-catenin mRNA expression was unaffected
Edlund et al., Mol Cell Biol 2005
(Prostatic Neoplasms) :
Smad7 was found to be required for
TGF-beta1 induced accumulation of
beta-catenin and LEF1 in human prostate cancer ( PC-3U ) cells as well as in human keratinocytes ( HaCaT cells )
Cordray et al., Dev Dyn 2005
:
We recently identified and characterized a novel Wnt-like
effect of
transforming growth factor-beta ( TGF-beta ) on
beta-catenin , the binding partner of Lef-1
Vogelmann et al., J Cell Sci 2005
:
By contrast, forced expression of PTEN clearly reduced the
TGFbeta(1) induced phosphorylation of
beta-catenin ... The
TGFbeta(1) induced
beta-catenin phosphorylation was also dependent on PI3-kinase and Ras activity
Jian et al., Genes Dev 2006
:
We show that
TGF-beta1 induces rapid nuclear translocation of
beta-catenin in MSCs in a Smad3 dependent manner
Caraci et al., Pharmacol Res 2008
:
At this time,
TGF-beta1 also
increased the total levels of
beta-catenin , an effect that was prevented by PD98059
Clifford et al., J Biol Chem 2008
:
Finally, we demonstrate that
TGFbeta(1) regulates TCF by modifying
beta-catenin phosphorylation via regulation of glycogen synthase kinase 3beta
Tanwar et al., Biol Reprod 2009
(Cell Transformation, Neoplastic...) :
By immunohistochemistry, we also show that both
transforming growth factor beta and the mammalian target of rapamycin are
induced by constitutive activation of
beta-catenin
Poon et al., BMC cell biology 2009
:
Both signaling pathways positively regulate fibroblast proliferation during this reparative process, and the effect of
transforming growth factor beta is partially
mediated by
beta-catenin ... In contrast to the situation in the regulation of cell proliferation, this effect of
transforming growth factor beta was not
mediated by
beta-catenin
Vi et al., BMC musculoskeletal disorders 2009
(Dupuytren Contracture) :
The aim of this study was to determine if a collagen enriched environment, similar to in vivo conditions, altered
beta-catenin accumulation by primary DD cells in the
presence or absence of
transforming growth factor-beta
Zheng et al., Am J Pathol 2009
(Fibrosis) :
TGF-beta1 induced the proteolytic shedding of E-cadherin, which caused the nuclear translocation of
beta-catenin , the transcriptional induction of Slug, and the repression of E-cadherin transcription in tubular epithelial cells
Wincewicz et al., Pathol Oncol Res 2010
(Colorectal Neoplasms) :
Beta-catenin accumulation is
suppressed by
TGF-beta1 ( transforming growth factor beta1 ) in intestinal epithelium suggesting negative feedback between these two factors
Zhang et al., J Biol Chem 2010
:
Our previous study demonstrated that
transforming growth factor ( TGF ) -beta activates
beta-catenin signaling through Smad3 interaction with beta-catenin in chondrocytes
He et al., J Biol Chem 2010
(MAP Kinase Signaling System) :
TGF-beta1 stimulated beta-catenin activation in tubular epithelial cells, and ectopic expression of
beta-catenin induced PAI-1 expression, whereas inhibition of beta-catenin abolished its induction
Liu et al., Sichuan Da Xue Xue Bao Yi Xue Ban 2011
:
Real-time PCR and Western blot demonstrated that 1 micromol/L
TGF-beta1 could
increase the expression of
beta-catenin ; C3a and C5a presented the similar inducible effect as TGF-beta1, which could be blocked by C3aR antagonist and C5aR antagonist ( C3aRA and C5aRA )