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CXCL1 — TLR2
Text-mined interactions from Literome
Hung et al., Nephrol Dial Transplant 2006
:
The LMPS
enhanced the secretion of CCL2/MCP-1 and CXCL8/interleukin-8
(CXCL8/IL-8) in TLR-defective human embryonic kidney (HEK) 293 cells only when transfected with a
TLR2 expressing plasmid
Bsibsi et al., Glia 2007
:
Moreover, the CD14 triggered
TLR2 mediated response in astrocytes
lead to the production of
CXCL8 , IL-6, and IL12p40, whereas typical TLR induced pro-inflammatory cytokines, like TNF-alpha and IL-1beta, were not produced at detectable levels
Méndez-Samperio et al., Arch Med Res 2008
:
Moreover, it is important to note that the levels of
CXCL8 secretion and mRNA were markedly ( 94 % )
reduced by functional blocking of both
TLR2 and TLR4
Wang et al., Blood 2008
:
We and others have reported that
Toll-like receptor ( TLR ) proteins are present on human neutrophils and that granulocyte-macrophage colony stimulating factor ( GM-CSF ) treatment
enhances IL-8 (
CXCL8 ) secretion in response to stimulation with TLR ligands
Lee et al., J Clin Immunol 2009
:
These results indicate that
TLR2-ROS signaling
plays a crucial role in the 30-kDa Ag-mediated expression of
CXCL8 and CCL2 in human monocytes
Lee et al., Cell Microbiol 2009
:
In addition,
TLR2 , Dectin-1 and, to an extent, TLR4 are
essential for the MU-mediated expression of
CXCL8 , CCL2 and LL-37 in keratinocytes ... In addition,
TLR2 , Dectin-1 and, to an extent, TLR4 are
essential for the MU-mediated expression of
CXCL8 , CCL2 and LL-37 in keratinocytes
Mersmann et al., Crit Care Med 2010
(Myocardial Infarction...) :
In HL-1 cells,
TLR2 activation amplified the expression of the receptor in a time dependent manner and
led to
CXCL1 release in a concentration dependent manner
Farges et al., Immunobiology 2011
:
We found that odontoblasts produce the pro-inflammatory cytokines interleukin (IL)-6 and
CXCL8 , as well as the immunosuppressive cytokine IL-10 in
response to
TLR2 agonists
Guerrero et al., Eur J Pharmacol 2012
:
Moreover, the joint production of TNF-a, IL-1ß and
CXCL1/KC by zymosan was
dependent on
TLR2/MyD88 signaling
Nischalke et al., J Hepatol 2012
(Disease Progression...) :
The CXCL1 rs4074 A allele is associated with enhanced
CXCL1 responses to
TLR2 ligands and predisposes to cirrhosis in HCV genotype 1-infected Caucasian patients ... In vitro carriers of the A allele produced greater amounts of
CXCL1 in
response to
TLR2-ligands including HCV core and NS3, and HCV infected carriers of the CXCL1 rs4074 A allele had higher CXCL1 serum levels than those with the G/G genotype
Oarada et al., J Nutr Biochem 2013
(Inflammation) :
TLR2 deficiency significantly
attenuated the refeeding induced increase in the liver expression of Cxcl10,
Cxcl1 , Icam-1 and A20
Sharma et al., J Leukoc Biol 2013
:
Our findings reveal a previously unrecognized role for S1P in regulating
TLR induced
CXCL8 secretion from human T cells