◀ Back to TNF
C9ORF3 — TNF
Text-mined interactions from Literome
Gueguen et al., Cell Biol Toxicol 2001
(Alzheimer Disease...) :
Among several cytokines tested, only
tumor necrosis factor (TNF)-alpha inhibited
apo E secretion in basal conditions in CCF-STTG1 human astrocytoma cells ... In the presence of 25-hydroxycholesterol,
TNF-alpha reduced
apo E secretion by 80 %, while interleukins ( IL ) IL-1beta, IL-6, and IL-2 had no significant effects
Lopez et al., Br J Haematol 2003
:
Apo-Tf or holo-Tf uniformly
induced TNF-alpha secretion in the cell supernatants from both groups
Schulze-Osthoff et al., EMBO J 1994
:
Whereas transcription factor NF-kappa B was readily activated by
TNF , activation was not
induced by triggering
APO-1/Fas
Duan et al., J Clin Invest 1995
:
Cytokines, including TNF alpha, have been identified in human lesions, therefore, we undertook a series of studies to evaluate the
effect of
TNF alpha on monocyte/macrophage
apo E production ... In summary,
TNF alpha
stimulates apo E gene transcription, mRNA abundance, and protein synthesis in the monocyte/macrophage in a phenotype-specific manner
Lens et al., J Immunol 1996
(Burkitt Lymphoma) :
In contrast to the strong effect of BCR ligation, APO-1 mAb induced apoptosis in only +/- 18 % of the Ramos cells after 48 h. Noticeably, addition of CD40 mAb or rTNF-alpha increased the percentage of cells ( +/- 46 % ) undergoing apoptosis, which correlated with an increase of
Fas/APO-1 membrane expression
induced by CD40 or
TNF-R ligation