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MED1 — PPARG

Pathways - manually collected, often from reviews:

• Reactome Reaction: PPARG → MED1 (direct_complex) Rachez et al., Nature 1999, Jepsen et al., J Cell Sci 2002, Bourbon et al., Mol Cell 2004, Malik et al., Trends Biochem Sci 2005, Rosenfeld et al., Genes Dev 2006, Yuan et al., Proc Natl Acad Sci U S A 1998
• Reactome Reaction: PPARG → MED1 (reaction) Gelman et al., J Biol Chem 1999, Rachez et al., Nature 1999, Jepsen et al., J Cell Sci 2002, Bourbon et al., Mol Cell 2004, Malik et al., Trends Biochem Sci 2005, Rosenfeld et al., Genes Dev 2006, Farmer et al., Cell Metab 2006, Lambe et al., Eur J Biochem 1996, Lemberger et al., Annu Rev Cell Dev Biol 1996, Mukherjee et al., J Biol Chem 1997, Yuan et al., Proc Natl Acad Sci U S A 1998
• Reactome Reaction: PPARG → MED1 (indirect_complex) Gelman et al., J Biol Chem 1999, Farmer et al., Cell Metab 2006, Lambe et al., Eur J Biochem 1996, Lemberger et al., Annu Rev Cell Dev Biol 1996, Mukherjee et al., J Biol Chem 1997

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind_translation Interaction: MED1 — PPARG (two hybrid) Albers et al., Mol Cell Proteomics 2005
• IRef Biogrid Interaction: MED1 — PPARG (direct interaction, two hybrid) Shao et al., Mol Endocrinol 2000*
• IRef Biogrid Interaction: MED1 — PPARG (direct interaction, pull down) Treuter et al., J Biol Chem 1999*
• IRef Biogrid Interaction: MED1 — PPARG (direct interaction, two hybrid) Albers et al., Mol Cell Proteomics 2005
• IRef Biogrid Interaction: MED1 — PPARG (physical association, affinity chromatography technology) Feige et al., J Biol Chem 2007*
• IRef Biogrid Interaction: MED1 — PPARG (direct interaction, fluorescent resonance energy transfer) Feige et al., J Biol Chem 2007*
• IRef Biogrid Interaction: MED1 — PPARG (direct interaction, two hybrid) Qin et al., Mol Cancer Ther 2004*
• IRef Biogrid Interaction: MED1 — PPARG (direct interaction, pull down) Kodera et al., J Biol Chem 2000*
• IRef Biogrid Interaction: MED1 — PPARG (direct interaction, two hybrid) Kodera et al., J Biol Chem 2000*
• IRef Biogrid Interaction: MED1 — PPARG (direct interaction, pull down) Yang et al., Mol Cell Biol 2000*
• IRef Biogrid Interaction: MED1 — PPARG (direct interaction, fluorescent resonance energy transfer) Iannone et al., Cytometry 2001
• IRef Intact Interaction: MED1 — PPARG (physical association, pull down) Surapureddi et al., Biochem Biophys Res Commun 2006*
• IRef Ophid Interaction: MED1 — PPARG (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Ge et al., Nature 2002 : Further indicative of a direct role for TRAP220 in PPAR gamma ( 2 ) function via the TRAP complex, TRAP functions directly as a transcriptional coactivator for PPAR gamma ( 2 ) in a purified in vitro system and interacts with PPAR gamma ( 2 ) in a ligand- and TRAP220 dependent manner
Ge et al., Mol Cell Biol 2008 : These results indicate that there is a conditional requirement for MED1/TRAP220 and that a direct interaction between PPARgamma and Mediator through MED1/TRAP220 is not essential either for PPARgamma stimulated adipogenesis or for PPARgamma target gene expression in cultured fibroblasts ... These results indicate that there is a conditional requirement for MED1/TRAP220 and that a direct interaction between PPARgamma and Mediator through MED1/TRAP220 is not essential either for PPARgamma stimulated adipogenesis or for PPARgamma target gene expression in cultured fibroblasts ... As Mediator is apparently essential for PPARgamma transcriptional activity, our data indicate the presence of alternative mechanisms for Mediator recruitment, possibly through intermediate cofactors or other cofactors that are functionally redundant with MED1/TRAP220