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EIF4E — RPTOR
Pathways - manually collected, often from reviews:
-
NCI Pathway Database mTOR signaling pathway:
mTORC1 complex (MTOR-MLST8-RPTOR)
→
4E-BP1/eIF4E complex (EIF4EBP1-EIF4E)
(modification, activates)
Gingras et al., Genes Dev 1999*, Nojima et al., J Biol Chem 2003, Schalm et al., Curr Biol 2003*, Beugnet et al., J Biol Chem 2003*, Brunn et al., Science 1997*, Burnett et al., Proc Natl Acad Sci U S A 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met):
mTORC1 complex (MTOR-MLST8-RPTOR)
→
4E-BP1/eIF4E complex (EIF4EBP1-EIF4E)
(modification, activates)
Moumen et al., Development 2007
Evidence: mutant phenotype, assay
-
Reactome Reaction:
EIF4E
→
RPTOR
(reaction)
Hara et al., Cell 2002, Ali et al., J Biol Chem 2005
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Prabhu et al., Oncogene 2007
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
Experiments with rapamycin and the Bcr-Abl inhibitor, imatinib mesylate, in Bcr-Abl expressing cell lines and primary CML cells indicated that Bcr-Abl and
mTORC1 induced formation of the translation initiation complex,
eIF4F
Grosso et al., PloS one 2011
:
In spite of this,
mTORc1 inhibition
reduces eIF4F complex formation, and depresses translocation of TOP mRNAs on polysomes
Fournier et al., Mol Cell Biol 2013
:
mTORC1 specifically drives the eIF4E mediated formation of SG through the phosphorylation of 4E-BP1, a key factor known to inhibit formation of the
mTORC1 dependent
eIF4E-eIF4GI interactions