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MAP2K3 — MAP3K5

Pathways - manually collected, often from reviews:

• BioCarta keratinocyte differentiation: FAS L/FAS/DAXX/ASK1 complex (FASLG-FAS-DAXX-MAP3K5) → MEK3 (MAP2K3) (modification, activates)
• BioCarta mapkinase signaling pathway: ASK1/TAK1/MAP3K11 (MAP3K5/MAP3K11/MAP3K7) → MEK3/MEK6 (MAP2K3/MAP2K6) (modification, activates)
• KEGG MAPK signaling pathway: MAP3K5 → MAP2K3 (protein-protein, phosphorylation)
• KEGG Amyotrophic lateral sclerosis (ALS): MAP3K5 → MAP2K3 (protein-protein, activation)
• Reactome Reaction: MAP3K5 → MAP2K3 (reaction) Takekawa et al., Mol Cell 2005*, Ichijo et al., Science 1997
• WikiPathways 4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression: Complex of MAP2K6-MAP2K3 → MAP3K5 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: MAP3K5 — MAP2K3 (physical association, affinity chromatography technology) McLaughlin et al., J Immunol 2006*
• IRef Biogrid Interaction: MAP3K5 — MAP2K3 (colocalization, biochemical) McLaughlin et al., J Immunol 2006*
• IRef Dip Interaction: MAP3K5 — MAP2K3 (physical association, anti bait coimmunoprecipitation) Yoon et al., Proc Natl Acad Sci U S A 2009*
• IRef Dip Interaction: MAP3K5 — MAP2K3 (physical association, anti tag coimmunoprecipitation) Yoon et al., Proc Natl Acad Sci U S A 2009*
• IRef Innatedb Interaction: MAP3K5 — MAP2K3 (unknown, -) McLaughlin et al., J Immunol 2006*
• IRef Innatedb Interaction: MAP3K5 — MAP2K3 (unknown, -) Jung et al., J Biol Chem 2010*
• IRef Intact Interaction: Complex of MAP2K3-ZNF622-MAP3K5 (association, anti bait coimmunoprecipitation) Seong et al., J Biol Chem 2011*
• IRef Intact Interaction: MAP3K5 — MAP2K3 (physical association, anti bait coimmunoprecipitation) Seong et al., J Biol Chem 2011*

Text-mined interactions from Literome

Tu et al., Cell Signal 2003 : They consist of a three-kinase module in which a mitogen activated protein kinase kinase kinase ( MAP3K ) activates a mitogen activated protein kinase kinase ( MAP2K ), which in turn activates MAPK
Huang et al., Biochem Biophys Res Commun 2003 : MAP3Ks are components of a three tiered protein kinase pathway in which a MAP3K phosphorylates and activates a mitogen activated protein kinase kinase ( MAP2K ), which in turn activates a mitogen activated protein kinase ( MAPK )
Madan et al., Mol Cell Biol 2013 : The phosphorylation of ASK-1 induces the activation of mitogen activated protein kinase kinases 4 and 7 ( MAP2K4/7 ) and MAP2K3/6 , which switches the c-Jun N-terminal protein kinase (JNK)/p38 dependent apoptotic cascades in cancer cells