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ANGPTL4 — PPARA

Pathways - manually collected, often from reviews:

• KEGG PPAR signaling pathway: Complex of PPARA-RXRA-RXRB-RXRG → ANGPTL4 (gene expression, expression)
• WikiPathways PPAR signaling pathway: Complex of RXRA-PPARA-RXRG-RXRB → ANGPTL4/ADIPOQ/PLIN1/MMP1/MMP1/SORBS1/FABP4 (mim-transcription-translation)
  

Text-mined interactions from Literome

Dutton et al., Br J Nutr 2008 : Angiopoietin-like protein 4 (Angptl4)/FIAF ( fasting induced adipose factor ) was first identified as a target for PPAR and to be strongly induced in white adipose tissue ( WAT ) by fasting
Staiger et al., Diabetes 2009 : LCFA activated peroxisome proliferator activated receptor ( PPAR)-delta, but not PPAR-alpha or -gamma, and pharmacological activation of PPAR-delta markedly induced ANGPTL4 production and secretion
Alex et al., Mol Cell Biol 2013 (Adenocarcinoma...) : At concentrations required for PPAR? activation and ANGPTL4 induction in colon adenocarcinoma cells, SCFA do not stimulate PPAR? in mouse 3T3-L1 and human SGBS adipocytes, suggesting that SCFA act as selective PPAR? modulators ( SPPARM ), which is supported by coactivator peptide recruitment assay and structural modeling
Korecka et al., Am J Physiol Gastrointest Liver Physiol 2013 : Although PPAR-? is not required for butyrate-driven intestinal ANGPTL4 expression, costimulating with PPAR-? ligands and SCFAs leads to additive increases in ANGPTL4 levels