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FCGR1A — STAT1
Text-mined interactions from Literome
Coccia et al., Int Immunol 1999
:
Taken together these results indicate that
STAT1 plays a pivotal role in the differentiation/maturation process of monocytes as an early transcription factor initially activated by adherence and then able to
modulate the expression of functional genes, such as ICAM-1 and
FcgammaRI
Aittomäki et al., Blood 2002
:
The basal activity of the natural
FcgammaRI promoter was strictly dependent on PU.1, and IFN-gamma induction
required both PU.1 and
Stat1 ... In contrast,
Stat1 did not interact with basal transcription machinery, but the Stat1 mediated activation of
FcgammaRI promoter critically
required CREB binding protein (CBP)/p300
Kårehed et al., Mol Immunol 2007
:
Our results suggest that IFN-gamma induced increase of
FcgammaRI expression
requires the integration of two signalling events : PKR dependent
Stat1 serine 727 phosphorylation, and activation of NFkappaB
Feldman et al., J Immunol 1995
:
IgG immune complexes
inhibit IFN-gamma induced transcription of the
Fc gamma RI gene in human monocytes by preventing the tyrosine phosphorylation of the p91 (
Stat1 ) transcription factor
Bovolenta et al., FEBS Lett 1996
:
This is the first demonstration that in human neutrophils, the induction by G-CSF of
Fc(gammaRI) gene expression may be
mediated by the binding of
STAT1 and STAT3 to the GRR sequence