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NOS2 — PRKACG

Text-mined interactions from Literome

Hayden et al., J Surg Res 1999 : Positive effects were then tested in the presence of KT5720 ( 10 ( -9 ) -10 ( -5 ) M ), the pharmacological inhibitor of PKA , and KT5823 ( 10 ( -9 ) -10 ( -5 ) M ), the pharmacological inhibitor of PKG. NO production was measured using the Greiss reaction, and mRNA abundance of the inducible NO synthase (iNOS) , using semiquantitative RT-PCR
Chen et al., J Biol Chem 1999 : The PKA inhibitors, KT-5720 and H8, reduced LPS induced NO release and inducible nitric oxide synthase (iNOS) expression ... The direct PKA activator, Bt ( 2 ) cAMP, caused concentration dependent NO release and iNOS expression, as confirmed by immunofluorescence studies
Chen et al., Br J Pharmacol 2000 : Moreover, the cyclic AMP/PKA dependent up-regulation of iNOS expression mediated by PGE ( 2 ) was drawn from the inhibitory effects of 2',5'-dideoxyadenosine, KT5720 and H-89
Won et al., Brain Res Mol Brain Res 2001 (Glioma) : This study has demonstrated the mechanism of protein kinase A (PKA) dependent inhibition of astrocytic nitric oxide production and inducible NO synthase mRNA expression induced by lipopolysaccharide ... The dose dependent inhibition of NO production and iNOS mRNA expression by compound SB203580 ( p38 inhibitor ) suggests the participation of p38 in PKA dependent inhibition of LPS induced NO production and iNOS mRNA expression
Chang et al., Cell Signal 2006 (MAP Kinase Signaling System) : LTA induced iNOS expression and NO release were inhibited by a non-selective COX inhibitor ( indomethacin ), a selective COX-2 inhibitor ( NS-398 ), an adenylyl cyclase ( AC ) inhibitor ( dideoxyadenosine, DDA ), and a protein kinase A (PKA) inhibitor ( KT-5720 ) ... Furthermore, both PGE2 and the direct PKA activator, dibutyryl-cAMP, also induced iNOS expression in a concentration dependent manner