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CD4 — CD40

Text-mined interactions from Literome

Moir et al., J Virol 1999 (Disease Susceptibility...) : CD40 Mediated induction of CD4 and CXCR4 on B lymphocytes correlates with restricted susceptibility to human immunodeficiency virus type 1 infection : potential role of B lymphocytes as a viral reservoir
Tan et al., J Immunol 1999 (Lymphocytic Choriomeningitis...) : Altogether, these results indicate that T cells have distinct costimulatory requirements : optimal CD8 responses require 4-1BBL dependent interactions, whereas CD4 responses are minimally affected by 4-1BB costimulation, but require CD40-CD40L and B7-dependent interactions
Lu et al., J Exp Med 2000 : Therefore, we conclude that CD4 ( + ) help comprises at least three components : CD40 dependent DC sensitization, CD40 independent DC sensitization, and direct lymphokine dependent CD4 ( + ) -CD8 ( + ) T cell communication
Lode et al., J Clin Invest 2000 (Melanoma, Experimental) : Melanoma immunotherapy by targeted IL-2 depends on CD4 ( + ) T-cell help mediated by CD40/CD40L interaction ... Three lines of evidence show that CD4 ( + ) T-cell help was mediated by CD40/CD40L interaction but not by endogenous IL-2 production
Chung et al., Eur J Immunol 2005 : In this study, we examined whether CD40 ligation affects the induction of CD4 and CD8 T cell tolerance in response to intestinal antigens
Wells et al., J Immunol 2008 (Melanoma, Experimental) : Immunization with two or more TLR agonists, anti-CD40 , IFN-gamma, and surfactant were sufficient to drive unprecedented levels of CD8 response to peptide or protein Ag and highly polarized Th1 CD4 responses
Tonti et al., Blood 2009 : CD4 ( + ) T ( Th ) -cell help to B lymphocytes requires cognate interaction and CD40 engagement
Xydia et al., Immunol Cell Biol 2011 : Combined activation of CD4 ( + ) and CD8 ( + ) memory T cells ( Tmem ) induced an increased expression of CD40L and CD40 on both populations ... Subsequently, CD40/CD40L caused a bi-directional stimulation of CD40 ( + ) CD4 ( + ) T(EM) by CD40L ( + ) CD8 ( + ) T(EM) and of CD40 ( + ) CD8 ( + ) T(EM) by CD40L ( + ) CD4 ( + ) T(EM) ... Subsequently, CD40/CD40L caused a bi-directional stimulation of CD40 ( + ) CD4 ( + ) T(EM) by CD40L ( + ) CD8 ( + ) T(EM) and of CD40 ( + ) CD8 ( + ) T(EM) by CD40L ( + ) CD4 ( + ) T(EM)
Baker et al., Eur J Immunol 2012 (Diabetes Mellitus, Type 2) : We have investigated the role of CD40 signaling in islet-reactive, diabetogenic CD4 ( + ) Th1 T-cell clones
Cho et al., Cancer Immunol Immunother 2013 (Melanoma, Experimental...) : The roles of various immune related pathways such as type-I IFN, CD40 costimulation , CD4 T cells, TLRs and the MDA5 RNA helicase were examined