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MMP9 — TNFSF12
Text-mined interactions from Literome
Kim et al., Circ J 2004
(Carotid Stenosis) :
TWEAK induced activation of
MMP-9 was mediated by activation of NF-kappaB
Polavarapu et al., J Neurosci 2005
:
TWEAK did not
increase MMP-9 activity or BBB permeability when injected into mice genetically deficient in the NF-kappaB family member p50
Kumar et al., J Immunol 2009
(Inflammation) :
TWEAK induced expression of proinflammatory genes such as
MMP-9 , CCL-2, and VCAM-1 was also reduced in TAK1 ( -/- ) MEF compared with wild-type MEF ... Furthermore, the activation of NF-kappaB and the expression of
MMP-9 in
response to
TWEAK involved the upstream activation of Akt kinase
Stephan et al., Journal of neuroinflammation 2013
:
Moreover, it has been shown by others that, when injected into mice brains,
TWEAK disrupts the architecture of the BBB and
induces expression of
matrix metalloproteinase-9 (MMP-9) in the brain
Pettersen et al., Int J Oncol 2013
(Cell Transformation, Neoplastic...) :
Moreover,
TWEAK induces the release of
matrix metalloprotease-9 (MMP-9) in neuroblastoma cells, suggesting that TWEAK may play a role in the invasive phase of neuroblastoma tumorigenesis