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FOXO4 — TNF
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Abid et al., J Biol Chem 2005
(Hyperplasia) :
PDGF-BB,
tumor necrosis factor-alpha , and insulin-like growth factor 1 treatment
resulted in the nuclear exclusion of
FoxO , whereas PDGF-BB alone down-regulated the FoxO target gene, p27 ( kip1 ), and enhanced cell survival and progression through the cell cycle
Li et al., Mol Cell Biol 2007
(Carotid Stenosis) :
TNF-alpha signaling
upregulates nuclear
FoxO4
Ludikhuize et al., Arthritis Rheum 2007
(Arthritis, Rheumatoid...) :
Immunoblotting was used to assess the interleukin-1beta (IL-1beta)- and
tumor necrosis factor alpha (TNFalpha) induced phosphorylation of FoxO1 and
FoxO4 in cultured fibroblast-like synoviocytes ( FLS ) and macrophages
Moylan et al., Am J Physiol Cell Physiol 2008
:
Instead,
TNF increases nuclear
Foxo4 protein ( +55 % )
Sheriff et al., Mol Cell Endocrinol 2012
(Burns...) :
DAG also reversed or attenuated the
TNF+IFN induced reduction in phosphorylation of Akt,
FOXO1 , 4E-BP-1, and GSK-3ß in myotubes