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MADCAM1 — TNF

Text-mined interactions from Literome

Connor et al., J Leukoc Biol 1999 (Acute Disease...) : No significant constitutive nor TNF-alpha induced expression of MAdCAM-1 was detected in skeletal muscle, brain, or heart ... In IL-10-deficient ( IL-10 k/o ) mice with no clinical or histological evidence of colitis, constitutive and TNF-alpha induced expression of MAdCAM-1 in the intestine, cecum, and colon was not different from those values obtained with healthy wild-type controls ... Taken together, these data demonstrate that TNF-alpha enhances surface expression of MAdCAM-1 in intestinal and colonic tissues to the same extent in both wild-type and IL-10 k/o mice with no colonic inflammation, whereas IL-10 k/o mice with active colitis exhibited a profound up-regulation of MAdCAM-1 in the colon
Oshima et al., Aliment Pharmacol Ther 2001 (Inflammatory Bowel Diseases) : To examine how agents currently used to treat inflammatory bowel disease affect MAdCAM-1 : induced by tnf-alpha in an in vitro model of inflammatory bowel disease ... Either dexamethasone or IL-10 : reduced TNF-alpha induced MAdCAM-1 : protein, mRNA and lymphocyte adhesion
Oshima et al., BMC gastroenterology 2001 (Inflammatory Bowel Diseases) : TNF-alpha induced endothelial MAdCAM-1 expression is regulated by exogenous, not endogenous nitric oxide ... DETA-NO, a long acting NO donor, and SperNO, a rapid releasing NO donor both inhibited TNF-alpha stimulated MAdCAM-1 expression in a concentration dependent manner ... Inhibition of endogenous NO production by either L-NAME, a non-selective NOS inhibitor, or by 1400 w, a selective iNOS inhibitor failed to induce, or potentiate TNF-alpha regulated MAdCAM-1 expression
Oshima et al., Am J Physiol Cell Physiol 2001 (Inflammatory Bowel Diseases...) : We used two endothelial lines [ bEND.3 ( brain ) and SVEC ( high endothelium ) ] to study the signal paths that regulate MAdCAM-1 expression in response to tumor necrosis factor (TNF)-alpha using RT-PCR, blotting, adhesion, and immunofluorescence
Sasaki et al., BMC gastroenterology 2002 : Melatonin reduces TNF-a induced expression of MAdCAM-1 via inhibition of NF-kappaB ... We examined how different doses of melatonin reduced endothelial MAdCAM-1 induced by TNF-a in an in vitro model of lymphatic endothelium ... MAdCAM-1 was induced by TNF-a
Sasaki et al., BMC gastroenterology 2003 (Inflammatory Bowel Diseases) : A human IL-10 expression vector was transfected into high endothelial venular ( ` HEV ' ) cells ( SVEC4-10 ) ; we then examined TNF-alpha induced lymphocyte adhesion to lymphatic endothelial cells and TNF-alpha induced expression of MAdCAM-1 and compared these responses to control monolayers ... IL-10 transfected endothelial cells expressed less than half ( 46 +/- 6.6 % ) of the MAdCAM-1 induced by TNF-alpha ( set as 100 % ) in non transfected ( control ) cells
Lindholm et al., Infect Immun 2004 : Furthermore, we show that MAdCAM-1 can be induced on human endothelial cells by tumor necrosis factor alpha (TNF-alpha) and gamma interferon
Sasaki et al., Am J Physiol Cell Physiol 2004 (Lymphoma...) : We show in this study that two cytochrome p-450 ( CYP450 ) inhibitors from Citrus paradis ( grapefruit ), bergamottin, and 6',7'-dihydroxybergamottin ( DHB ) block tumor necrosis factor (TNF)-alpha stimulated expression of MAdCAM-1 in cultured endothelial cells and also reduce alpha ( 4 ) beta ( 7 ) -dependent lymphocyte adhesion ... Bergamottin ( 20-50 microM ) or DHB ( 10-30 microM ) pretreatment dose-dependently reduced TNF-alpha mediated expression of MAdCAM-1 and lymphocyte adhesion ... SKF-525a, a specific CYP450 inhibitor, also blocked the expression of MAdCAM-1 mediated by TNF-alpha
Sasaki et al., BMC physiology 2005 : We found that troglitazone ( 10-40 microM ), significantly reduced the TNF-alpha ( 1 ng/ml ) mediated induction of endothelial MAdCAM-1 in a dose dependent manner, achieving a 34.7 % to 98.4 % reduction in induced MAdCAM-1
Ando et al., Inflamm Bowel Dis 2005 (Second Messenger Systems) : TNF-alpha induced MAdCAM-1 in a dose dependent manner by 24 hours ... In vitro, MAdCAM-1 can be induced on colon endothelial cells by TNF-alpha stimulation and may represent a useful model to study microvascular injury in the large intestine
Ando et al., Lymphat Res Biol 2005 : SV-LEC also expresses MAdCAM-1 in response to TNF-alpha , an effect seen in VEC, but not AEC
Ando et al., BMC physiology 2007 : Time and dose dependent expression of MAdCAM-1 in response to TNF-alpha , IL-1 beta and IFN-gamma was studied by immunoblotting
Mizushima et al., Am J Physiol Gastrointest Liver Physiol 2010 (Colitis) : Blockage of angiotensin II type 1 receptor regulates TNF-alpha induced MAdCAM-1 expression via inhibition of NF-kappaB translocation to the nucleus and ameliorates colitis ... AT1R blocker significantly suppressed MAdCAM-1 expression induced by TNF-alpha , but did not inhibit phosphorylation of p38 MAPK or of IkappaB that modulate MAdCAM-1 expression
Liaskou et al., Hepatology 2011 (Cholangitis, Sclerosing...) : In this study, we show that deamination of methylamine ( MA ) by vascular adhesion protein 1 (VAP-1) [ a semicarbazide-sensitive amine oxidase ( SSAO ) expressed in the human liver ] in the presence of tumor necrosis factor a induces the expression of functional MAdCAM-1 in hepatic endothelial cells and in intact human liver tissue ex vivo
Biancheri et al., Inflamm Bowel Dis 2013 (Crohn Disease) : As tumor necrosis factor alpha (TNF)-a, a cytokine centrally involved in CD, modulates gut endothelial adhesion molecules, we here explored the in vivo and ex vivo effects of TNF-a blockade on MAdCAM-1 expression in CD
Takeuchi et al., Proc Natl Acad Sci U S A 1995 : Expression of MAdCAM-1 is induced in the murine endothelial cell line bEnd.3 by tumor necrosis factor alpha (TNF-alpha) , interleukin 1, and bacterial lipopolysaccharide ... These findings establish that, as with other endothelial cell adhesion molecules, transcriptional induction of MAdCAM-1 by TNF-alpha requires activated NF-kappa B proteins
Ettinger et al., Int Immunol 1998 : Splenic MAdCAM-1 expression, follicular dendritic cell localization and normal Peyer 's patch development all require both surface LT-alphabeta and TNF activity