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OPRM1 — TNF

Text-mined interactions from Literome

Kraus et al., Mol Pharmacol 2003 : The role of nuclear factor kappaB in tumor necrosis factor regulated transcription of the human mu-opioid receptor gene
Kraus et al., J Neuroimmunol 2006 (Neuroblastoma) : Earlier investigations demonstrated up-regulated mu-opioid receptor expression in neuronal and immune cells in response to IL-1, IL-4, IL-6 and TNF-alpha
Bonnet et al., Anesth Analg 2008 (Inflammation) : The mu opioid receptor mediates morphine induced tumor necrosis factor and interleukin-6 inhibition in toll-like receptor 2-stimulated monocytes ... Mu opioid receptor activation specifically mediated this morphine induced TNF and IL-6 inhibition in monocytes ... The mu opioid receptor was not involved in this morphine induced TNF inhibition in PBMCs. Antiinflammatory cytokines : IL-10 was not a factor for the inhibition of TNF and IL-6 production after PGN stimulation in either monocytes or PBMCs cultures ... The mu opioid receptor mediates morphine induced TNF and IL-6 inhibition in PGN stimulated monocytes, but not in PBMCs
Kraus et al., Front Biosci (Schol Ed) 2009 : In this review, the up-regulation of human mu-opioid receptor gene expression in neuronal and immune effector cells by interleukin-1, interleukin-4, interleukin-6 and tumor necrosis factor , as well as its down-regulation by interferon-gamma and granulocyte/macrophage colony stimulating factor will be summarized along with molecular mechanisms, such as transcription factor-promoter-interactions