Gene interactions and pathways from curated databases and text-mining

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TNF — VWF

Text-mined interactions from Literome

Shang et al., Hunan Yi Ke Da Xue Xue Bao 2000 : 2. Compared with the control, TNF alpha promoted the release of vWF from endothelial cells ( 13.28 +/- 4.76 vs. 6.42 +/- 2.84, P < 0.01 ) and BHD inhibited the effect of TNF alpha ( P < 0.01 ) ... BHD can inhibit the expression of TF and the release of vWF induced by TNF alpha
van der Poll et al., Thromb Haemost 1992 : Tumor necrosis factor induces von Willebrand factor release in healthy humans ... To investigate the effect of TNF on the release of von Willebrand factor (vWF) into the circulation, we performed a controlled study in six healthy men, sequentially measuring the plasma concentrations of vWF antigen after a bolus intravenous injection of recombinant human TNF ( 50 micrograms/m2 ) ... TNF induced a marked increase in vWF antigen plasma levels, becoming significant after 45 min and peaking after 4 h ( percentage increase from base line : 351 +/- 46 ; p less than 0.0001, TNF versus saline )
Espirito Santo et al., Atherosclerosis 2004 (Arteriosclerosis...) : Printanor and kyolic treatment did not affect plasma lipids, markers of inflammation ( serum amyloid A, serum-soluble intercellular adhesion molecule-1, and blood-leukocytes tumor necrosis factor-alpha (TNFalpha) production ) and vascular activation ( plasma von Willebrand factor (vWF) )
Antonova et al., Bull Exp Biol Med 2007 : Tumor necrosis factor and lipopolysaccharide did not stimulate secretion of von Willebrand factor , but significantly increased the expression of ICAM-1