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AQP5 — TNF

Text-mined interactions from Literome

Towne et al., J Biol Chem 2001 (Edema...) : Tumor necrosis factor-alpha inhibits aquaporin 5 expression in mouse lung epithelial cells ... Activation of the p55 TNF-alpha receptor ( TNFR1 ) with an agonist antibody is sufficient to cause decreased AQP5 expression, demonstrating that the TNF-alpha effect is mediated through TNFR1 ... Inhibition of nuclear factor kappaB (NF-kappaB) translocation to the nucleus blocks the effect of TNF-alpha on AQP5 expression, indicating that activation of NF-kappaB is required, whereas inhibition of extracellular signal regulated or p38 mitogen activated protein kinases showed no effect
Yamamura et al., J Cell Mol Med 2012 : Although we also investigated the role of NF-?B activity in the TNF-a induced suppression of AQP5 expression in NS-SV-AC cells, we detected similar TNF-a suppression of AQP5 expression in non transfected cells and in a super-repressor form of I?Ba cDNA transfected cell clones