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CD4 — TNF
Text-mined interactions from Literome
El-Sheikh et al., J Autoimmun 1999
(Diabetes Mellitus, Type 1) :
Depletion of either
CD4 ( + ) or CD8 ( + ) T cells may prevent beta-cell destruction by decreasing IFN-gamma and IL-10 production in islets and
increasing IL-4 and
TNF-alpha production systemically
Martin et al., Infect Immun 2001
:
In a coculture system, CT-treated
CD4 ( + ) T cells
induced significantly less
TNF-alpha and IL-12 p70 production by both autologous monocytes and monocyte derived dendritic cells than either LT-IIa- or LT-IIb treated CD4 ( + ) T cells
Tsukadaira et al., Int Arch Allergy Immunol 2001
:
Theophylline inhibits
TNF-alpha induced
CD4 expression on human eosinophils and CD4+ eosinophil migration
Romas et al., Bone 2002
(Arthritis, Rheumatoid) :
Production of
tumor necrosis factor-alpha (TNF-alpha) and other proinflammatory cytokines in RA is largely
CD4 ( + ) T-cell
dependent and mostly a result of interferon-gamma (IFN-gamma) secretion
Brown et al., J Immunol 2002
(Graft vs Host Disease...) :
The present studies were designed to evaluate whether
TNF-TNFR2 interactions were
involved in the in vivo generation of
CD4 ( + ) T cell mediated intestinal graft-versus-host disease ( GVHD ) in the ( C57BL/6J ( hereafter called B6 ) -- > B6 x B6.C-H-2 ( bm12 ) ( bm12 ) ) F ( 1 ) GVHD model
Banda et al., J Immunol 2003
(Arthritis, Experimental) :
The production of IFN-gamma,
TNF-alpha , and IL-1beta in cultured spleen cells was
reduced by in vivo treatment with low dose, but not high dose, mIL-18BP. FACS analysis showed a slight decrease in NK cells and an increase in
CD4 ( + ) T cells in spleens of mice treated with mIL-18BP
Brown et al., J Immunol 2003
(Colonic Diseases...) :
These findings indicate that
TNF promotes
CD4 ( + ) T cell alloproliferation, IFN-gamma responses, and intestinal GVHD by IL-12 independent mechanisms
Hata et al., J Clin Invest 2004
(Arthritis, Experimental...) :
Thus, IL-6, IL-1,
TNF-alpha , and IL-10 play distinct roles in the development of SKG arthritis ; arthritogenic
CD4 ( + ) T cells are not
required to skew to either Th1 or Th2 ; and the appearance of rheumatoid factor is independent of joint inflammation
Ferland et al., J Immunol 2004
:
TNF-pretreatment increased surface membrane
CD4 ( + ) expression by 6-fold as previously described, and increased IL-16 induced cell migration by 2.2-fold
Merrill et al., J Virol 1992
:
Soluble recombinant
CD4 did not
block TNF alpha and IL-1 production
Cassatella et al., Immunology 1992
:
In this study we investigated the
effects of
TNF and IFN-gamma on the expression of the
CD4 protein and messenger RNA ( mRNA ) in the two myeloid cell lines, ML3 and HL-60 ... We observed that
CD4 antigen expression on ML3 cells is almost undetectable and that
TNF and IFN-gamma
induced CD4 antigen expression on these cells
Singh et al., J Virol 2007
(Acute Disease...) :
Indirect
regulation of
CD4 T-cell responses by
tumor necrosis factor receptors in an acute viral infection
Yamada et al., Clin Immunol 2007
(Arthritis, Rheumatoid) :
Furthermore IL-15 stimulated CD57 ( + ) CD28 ( - )
CD4 ( + ) T cells
induced TNF-alpha production from monocytes
Cambos et al., Int J Parasitol 2008
(Anemia...) :
Interestingly, a potent
induction of
TNF-alpha and IFN-gamma production by
CD4+ and CD90 ( - ) lymphocytes was measured in DS-infected mice, which also suffered severe anaemia earlier than non depleted infected controls
Noguchi et al., Int Immunol 2007
(Colitis) :
The blockade of IL-6 signaling enhanced the generation of IL-4- and IL-10 producing
CD4 ( + ) T cells, and
inhibited up-regulation of
tumor necrosis factor -alpha mRNA expression in the colon
Cornejo-Garcia et al., Allergy 2007
(Drug Hypersensitivity...) :
In DR, IFN-gamma,
TNF-alpha and T-bet
increased significantly in both
CD4 and CD8 subpopulations, depending on the clinical severity
Nishikawa et al., Cancer Res 2008
:
We previously found that a Salmonella typhimurium vector engineered to secrete soluble tumor antigen induces
CD4 ( + ) T cells resistant to CD4 ( + ) CD25 ( + ) regulatory T cells ( Treg ) and that glucocorticoid induced
tumor necrosis factor receptor family related gene ( GITR ) signal is
involved in the development of this resistance
Hassan et al., Leuk Res 1991
(Leukemia, Hairy Cell) :
TNF induced expression of
CD4 and CD71, increased the intensity of HLA-DR, CD25, CD11c and CD13 expression and decreased both the intensity and frequency of sIg and cIg positivity ... alpha-IFN decreased CD25 expression, the tartrate-resistant acid phosphatase activity ( TRAP ), reduced the
TNF induced
CD4 and CD71 expression and antagonized the TNF effect on the Ig expression
Du et al., Chin J Integr Med 2009
(Carcinoma, Non-Small-Cell Lung...) :
The level of CD3 ( + ),
CD4 ( + ), the ratio of CD4 and CD8 ( + ), IgA, IgM, IgG and IL-2 decreased in patients with NSCLC on day 1 after operation, and the level of CD8 and
TNF-alpha increased compared to pre-operation
Zhou et al., Zhonghua Yi Xue Za Zhi 2009
(Inflammation...) :
The level of
TNFalpha decreased, and the numbers of CD ( 3 ) ( + ) and
CD(4) ( + ) T lymphocytes
increased significantly on day 4 in Combined Therapy Group ( P < 0.05 or P < 0.01 )
Robinet et al., J Immunol 1990
:
TNF did not
affect the expression of LFA1, CD2,
CD4 , and CD8, molecules that are associated with CTL-target interactions, on responder cells
Ryba et al., Cytokine 2011
(Diabetes Mellitus, Type 1...) :
It indicates that
TNF reduces the number and frequency of regulatory
CD4 ( + ) Foxp3 ( + ) T cells in children with diabetes type 1 and that in vitro treatment with anti-TNF antibody seems to rescue this cell subset from its defective effects
Kothari et al., Indian journal of clinical biochemistry : IJCB 2006
:
Despite the rising IL-10 mRNA levels,
TNF-a mRNA levels
increased with severity of HIV and decrease in
CD(4) ( + ) T cell counts
Piguet et al., J Exp Med 1989
(Pulmonary Fibrosis) :
Depletion of the
CD4 and CD8 T lymphocytes by an in vivo treatment with mAb
prevented the bleomycin induced increase of
TNF mRNA level and fibrosis
Hershkoviz et al., J Immunol 1994
:
When TNF-alpha was immobilized on FN, less
TNF-alpha was
required to induce
CD4+ cell binding to FN. Soluble, and to a greater extent FN-bound, TNF-alpha synergizes with PMA to intensify protein tyrosine phosphorylation in FN-bound CD4+ cells, and this effect of TNF-alpha was inhibited by inhibitors of tyrosine kinase
Oyaizu et al., Blood 1994
:
In addition,
CD4XL resulted in the induction of interferon-gamma (IFN-gamma) and
tumor necrosis factor-alpha (TNF-alpha) in the absence of interleukin-2 (IL-2) and IL-4 secretion in PBMCs
Oyaizu et al., Adv Exp Med Biol 1995
(HIV Infections) :
CD4XL in PBMC also
resulted in induction of the cytokines INF-tau and
TNF-alpha in the absence of IL-2 and IL-4 secretion
Hossain et al., Immunology 1996
:
Our data indicate that
TNF-alpha induced
CD4 expression on human eosinophils is dependent on protein synthesis and may be dependent on tyrosine kinase activity
Tamma et al., Blood 1997
:
CD4 cross linking ( CD4XL )
induces RAS activation and
tumor necrosis factor-alpha secretion in CD4+ T cells ... CD4+ T cells expressing dn-ras secreted significantly reduced levels of
TNF-alpha in
response to
CD4XL
Yu et al., Neuroimmunomodulation 1998
:
IL-1-alpha and
TNF-alpha differentially
regulate CD4 and Mac-1 expression in mouse microglia ... The addition of IL-1alpha, but not
TNF-alpha , also
led to an increase in
CD4 expression on plate supported microglia with a similar dose response and time course